UPEC, Univ Paris Est Creteil, 94000, Créteil, France.
Fondation Fondamental, 94000, Créteil, France.
Curr Psychiatry Rep. 2024 May;26(5):253-263. doi: 10.1007/s11920-024-01500-9. Epub 2024 Apr 16.
A global study of multimorbidity in schizophrenia, especially of the association with physical conditions, might offer much needed etiological insights.
Our review suggests that life-style factors and medication related to schizophrenia are only part of the explanation of the increase in risk for cardiovascular, metabolic, pulmonary disorders, and some cancers. Positive associations with autoimmune disorders (with the exception of rheumatoid arthritis) and epilepsy are promising avenues of research but to date have not been fully exploited. The same holds for the negative comorbidity seen for rheumatoid arthritis and some cancers (e.g., prostate). As a whole, our review suggests that most of the explored conditions have a different prevalence in schizophrenia than in the general population. Several hypotheses emerged from this review such as the role of immune and genetic factors, of sex hormones, and of more general variability factors.
对精神分裂症的全球共病研究，特别是与身体状况的关联，可能提供急需的病因学见解。
我们的综述表明，与精神分裂症相关的生活方式因素和药物只是增加心血管、代谢、肺部疾病和某些癌症风险的部分原因。与自身免疫性疾病（类风湿关节炎除外）和癫痫的阳性关联是有希望的研究途径，但迄今为止尚未得到充分利用。类风湿关节炎和某些癌症（如前列腺癌）的负共病也是如此。总的来说，我们的综述表明，大多数已探索的疾病在精神分裂症患者中的患病率与普通人群不同。从这项综述中出现了一些假设，如免疫和遗传因素、性激素以及更普遍的变异性因素的作用。
