Morera Daley, Miller Brian J
Medical College of Georgia, Augusta University, Augusta, GA, United States.
Department of Psychiatry and Health Behavior, Augusta University, Augusta, GA, United States.
Schizophr Res. 2024 Feb;264:90-94. doi: 10.1016/j.schres.2023.12.001. Epub 2023 Dec 19.
Type 2 diabetes (T2DM) is common in patients with schizophrenia and non-affective psychosis. These patients also have an increased prevalence of a family history of T2DM. We performed a systematic review and meta-analysis of the association between a family history of T2DM and schizophrenia.
We searched electronic databases from inception until July 2022 for studies of a family history of T2DM or gestational diabetes in patients with schizophrenia and controls. We performed random effects meta-analysis, calculating odds ratios (ORs) and 95 % confidence intervals (CI) and meta-regression analyses.
Nine studies were included, comprising 2953 patients with non-affective psychosis and 4484 controls. Schizophrenia was associated with an over two-fold increased odds of a family history of T2DM or gestational diabetes (OR = 2.18, 95 % CI 1.61-2.96, p < 0.01). In meta-regression analyses, age, sex, study quality score, and year of publication were all unrelated to the association.
We found that patients with schizophrenia had a 2.2-fold increased odds of a family history of T2DM versus controls. This association may be relevant to both the pathophysiology of schizophrenia and the reported increased risk of development of diabetes with antipsychotic treatment.
2型糖尿病（T2DM）在精神分裂症和非情感性精神病患者中很常见。这些患者的T2DM家族史患病率也有所增加。我们对T2DM家族史与精神分裂症之间的关联进行了系统评价和荟萃分析。
我们检索了从数据库建立至2022年7月的电子数据库，以查找有关精神分裂症患者和对照中T2DM家族史或妊娠期糖尿病的研究。我们进行了随机效应荟萃分析，计算优势比（OR）和95%置信区间（CI）以及荟萃回归分析。
纳入9项研究，包括2953例非情感性精神病患者和4484例对照。精神分裂症与T2DM或妊娠期糖尿病家族史的优势比增加两倍以上相关（OR = 2.18，95%CI 1.61 - 2.96，p < 0.01）。在荟萃回归分析中，年龄、性别、研究质量评分和发表年份均与该关联无关。
我们发现，与对照相比，精神分裂症患者有T2DM家族史的优势比增加了2.2倍。这种关联可能与精神分裂症的病理生理学以及抗精神病药物治疗导致糖尿病发生风险增加的报道均相关。
