Heart Failure Care Unit, Heart Failure Center, Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union of Medical College, National Center for Cardiovascular Diseases, Beijing, China.
Cardiology, ASST Spedali Civili and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia.
J Cardiovasc Med (Hagerstown). 2024 Jun 1;25(6):399-419. doi: 10.2459/JCM.0000000000001616. Epub 2024 Apr 26.
Hypertrophic cardiomyopathy is an important cause of heart failure and arrhythmias, including sudden death, with a major impact on the healthcare system. Genetic causes and different phenotypes are now increasingly being identified for this condition. In addition, specific medications, such as myosin inhibitors, have been recently shown as potentially able to modify its symptoms, hemodynamic abnormalities and clinical course. Our article aims to provide a comprehensive outline of the epidemiology, diagnosis and treatment of hypertrophic cardiomyopathy in the current era.
肥厚型心肌病是心力衰竭和心律失常（包括猝死）的重要病因，对医疗体系有重大影响。目前，这种疾病的遗传病因和不同表型越来越多地被发现。此外，最近还发现了一些特定的药物，如肌球蛋白抑制剂，可能具有改善其症状、血液动力学异常和临床过程的潜力。我们的文章旨在提供一个全面的概述，涵盖肥厚型心肌病在当前时代的流行病学、诊断和治疗。
