Zhao Taiqi, Duan Suying, Li Jiaqi, Zheng Honglin, Liu Chenyang, Zhang Hang, Luo Haiyang, Xu Yuming
Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China.
Henan Key Laboratory of Cerebrovascular Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China.
Heliyon. 2024 Apr 2;10(8):e29141. doi: 10.1016/j.heliyon.2024.e29141. eCollection 2024 Apr 30.
Over 50 genetic human disorders are attributed to the irregular expansion of microsatellites. These expanded microsatellite sequences can experience bidirectional transcription, leading to new reading frames. Beyond the standard AUG initiation or adjacent start codons, they are translated into proteins characterized by disease-causing amino acid repeats through repeat-associated non-AUG translation. Despite its significance, there's a discernible gap in comprehensive and objective articles on RAN translation. This study endeavors to evaluate and delineate the contemporary landscape and progress of RAN translation research via a bibliometric analysis. We sourced literature on RAN translation from the Web of Science Core Collection. Utilizing two bibliometric analysis tools, CiteSpace and VOSviewer, we gauged individual impacts and interactions by examining annual publications, journals, co-cited journals, countries/regions, institutions, authors, and co-cited authors. Following this, we assessed the co-occurrence and bursts of keywords and co-cited references to pinpoint research hotspots and trending in RAN translation. Between 2011 and 2022, 1317 authors across 359 institutions from 34 countries/regions contributed to 250 publications on RAN translation, spread across 118 academic journals. This article presents a systematic, objective, and comprehensive analysis of the current literature on RAN translation. Our findings emphasize that mechanisms related to ALS/FTD are pivotal topics in the realm of RAN translation, with cellular stress and the utilization of small molecule marking the trending research areas.
超过50种人类遗传疾病被归因于微卫星的不规则扩增。这些扩增的微卫星序列可经历双向转录，从而产生新的阅读框。除了标准的AUG起始密码子或相邻的起始密码子外，它们还通过重复相关的非AUG翻译被翻译成以致病氨基酸重复为特征的蛋白质。尽管其具有重要意义，但关于RAN翻译的全面且客观的文章仍存在明显空白。本研究旨在通过文献计量分析来评估和描绘RAN翻译研究的当代格局与进展。我们从科学网核心合集获取了关于RAN翻译的文献。利用两种文献计量分析工具CiteSpace和VOSviewer，我们通过考察年度出版物、期刊、共被引期刊、国家/地区、机构、作者以及共被引作者来衡量个体影响和相互作用。在此之后，我们评估了关键词和共被引参考文献的共现与爆发情况，以确定RAN翻译的研究热点和趋势。在2011年至2022年期间，来自34个国家/地区的359个机构的1317位作者发表了250篇关于RAN翻译的论文，这些论文分布在118种学术期刊上。本文对当前关于RAN翻译的文献进行了系统、客观且全面的分析。我们的研究结果强调，与肌萎缩侧索硬化症/额颞叶痴呆（ALS/FTD）相关的机制是RAN翻译领域的关键主题，细胞应激和小分子的利用是研究的热门领域。
