Fujiwara Michimasa, Kimura Takashi, Ohira Junya, Inotani Motohiro, Sakane Tomoko, Iwase Mizue, Yamashita Sadanori, Araki Tooru
Department of Pediatrics, NHO Fukuyama Medical Center, Fukuyama, Japan.
Front Allergy. 2024 Apr 2;5:1395807. doi: 10.3389/falgy.2024.1395807. eCollection 2024.
Most adult cases of hen's egg allergy are carried over from childhood, and new-onset adult cases are rare. Such cases may result from cross-reactivity or sensitization by inhalation. Here we present a rare case of adult-onset egg allergy due to monosensitization to ovalbumin (Gal d 2) with an unclear sensitization pathway. A 27-year-old woman developed recurrent gastrointestinal symptoms after ingestion of raw and under-cooked eggs. She had never suffered from atopic dermatitis or food allergies. She had never kept birds as pets and had no history of exposure to egg allergens. Prick to prick testing was positive only with raw egg white. Specific IgE testing revealed monosensitization to Gal d 2. She was advised to avoid raw and undercooked eggs and her symptoms resolved. In the management of adult-onset egg allergy, evaluation of allergen components will lead to appropriate elimination guidelines, and investigation of sensitization pathways may help identify the cause of this disease.
大多数成人鸡蛋过敏病例是儿童时期遗留下来的,成人新发病例很少见。此类病例可能是由交叉反应或吸入致敏引起的。在此,我们报告一例罕见的成人期鸡蛋过敏病例,该病例因对卵清蛋白(Gal d 2)单敏化且致敏途径不明。一名27岁女性在摄入生鸡蛋和未煮熟的鸡蛋后出现反复的胃肠道症状。她从未患过特应性皮炎或食物过敏。她从未养过鸟类作为宠物,也没有接触过鸡蛋过敏原的病史。点刺试验仅对生蛋清呈阳性。特异性IgE检测显示对Gal d 2单敏化。建议她避免食用生鸡蛋和未煮熟的鸡蛋,其症状得到缓解。在成人期鸡蛋过敏的管理中,评估过敏原成分将得出适当的消除指南,而对致敏途径的调查可能有助于确定该病的病因。