Department of Internal Medicine, College of Medicine, Najran University, Najran, Saudi Arabia.
Department of Physiology, College of Medicine, King Khalid University, Abha, Saudi Arabia.
Saudi J Gastroenterol. 2024 May 1;30(3):162-167. doi: 10.4103/sjg.sjg_346_23. Epub 2024 Apr 17.
Globus pharyngeus is a clinical condition, wherein, a patient senses a lump or a foreign body in the throat with a tightening or choking feeling. A strong association between globus pharyngeus and gastroesophageal reflux disease (GERD) was reported. Therefore, we sought to investigate the predictive factors of globus pharyngeus in patients with established GERD and fit a predictive scoring model for globus pharyngeus.
In this case-control study, 143 patients having globus pharyngeus along with GERD ( case ) and 109 patients having globus pharyngeus without GERD ( control ) were enrolled. Data comprising demographics, comorbidities, and psychosocial stress levels were recorded. The predictive factors of globus pharyngeus in patients with GERD were unraveled, and a predictive scoring model was fit for globus pharyngeus.
Proton pump inhibitor usage in the case group was significantly higher compared to controls (63.63% vs 24.78%, P < 0.001), and differences in Hiatus Hernia and Stress levels were highly significant between the two groups ( P < 0.001). Multivariate logistic regression revealed that variates, Hiatus Hernia, psychosocial stress, and age were highly significant ( P < 0.001) independent predictors of globus pharyngeus. Using the regression coefficients of all the independent predictor variables, a predictive scoring model was fitted, which yielded an area under receiver operating characteristic (AUROC) curve of 78.9.
Hiatus hernia, psychosocial stress, and age are significant independent predictors of globus pharyngeus in GERD, and our predictive scoring model may help in identifying patients at higher odds of experiencing globus pharyngeus and modulate treatment accordingly.
咽部异物感是一种临床病症，患者会感到喉咙有异物感或紧绷感，有时还会伴有窒息感。有研究报道称，咽部异物感与胃食管反流病（GERD）之间存在较强的关联。因此，我们试图研究已确诊 GERD 患者中咽部异物感的预测因素，并建立预测咽部异物感的评分模型。
在这项病例对照研究中，共纳入了 143 例同时患有 GERD 和咽部异物感的患者（病例组）和 109 例仅患有咽部异物感而无 GERD 的患者（对照组）。记录了患者的人口统计学、合并症和心理社会压力水平等数据。探讨 GERD 患者中咽部异物感的预测因素，并建立预测咽部异物感的评分模型。
病例组中使用质子泵抑制剂的比例明显高于对照组（63.63% vs 24.78%，P<0.001），两组之间食管裂孔疝和压力水平的差异具有统计学意义（P<0.001）。多变量逻辑回归显示，食管裂孔疝、心理社会压力和年龄是咽部异物感的高度显著（P<0.001）独立预测因素。使用所有独立预测变量的回归系数拟合了一个预测评分模型，该模型的受试者工作特征曲线下面积（AUROC）为 78.9。
食管裂孔疝、心理社会压力和年龄是 GERD 患者咽部异物感的重要独立预测因素，我们的预测评分模型有助于识别更有可能出现咽部异物感的患者，并相应地调整治疗方案。
