Behrendt H, Wenniger-Prick L M
Med Pediatr Oncol. 1985;13(6):352-6. doi: 10.1002/mpo.2950130610.
A 12-year-old Caucasian boy developed leukemic hyphema with iris infiltration as the only relapse site during the third complete remission of his acute lymphoblastic leukemia. With high-dose methotrexate, high-dose cytosine-arabinoside plus teniposide, and a 5-week course of vincristine, prednisolone, and L-asparaginase, a complete remission could be achieved. Maintenance treatment was reinstituted for 1 year. However, after stopping the treatment, the iris infiltrate reappeared, and this time the eye was irradiated after chemotherapeutic reinduction. Seven months later, the boy remains in complete remission. The pathogenesis of leukemic iris infiltration is discussed briefly.
一名12岁的白种男孩在急性淋巴细胞白血病第三次完全缓解期间，出现白血病性前房积血伴虹膜浸润，这是唯一的复发部位。通过大剂量甲氨蝶呤、大剂量阿糖胞苷加替尼泊苷，以及为期5周的长春新碱、泼尼松龙和L-天冬酰胺酶治疗，实现了完全缓解。重新开始维持治疗1年。然而，停止治疗后，虹膜浸润再次出现，这次在化疗再诱导后对眼睛进行了放疗。7个月后，该男孩仍处于完全缓解状态。本文简要讨论了白血病性虹膜浸润的发病机制。
