密罗香烷酮类：从弯梗露珠草内生真菌中分离得到的双环细胞毒性内酯。

Myrotheciumones: bicyclic cytotoxic lactones isolated from an endophytic fungus of Ajuga decumbens.

机构信息

School of Pharmaceutical Sciences, Xiamen University, South Xiangan Road, Xiamen, Fujian 361102, China.

出版信息

Bioorg Med Chem Lett. 2014 Jun 1;24(11):2504-7. doi: 10.1016/j.bmcl.2014.04.016. Epub 2014 Apr 13.

DOI:10.1016/j.bmcl.2014.04.016

Abstract

Two new bicyclic lactones, myrotheciumones A (1) and B (2) which possessed a rare ring-fusion system were isolated from Myrothecium roridum (M. roridum), an endophytic fungus of the medicinal herb plant Ajuga decumbens (A. decumbens) via an in vitro cytotoxicity assay. Structures were deduced from 1D and 2D NMR (Nuclear magnetic resonance) data. Myrotheciumone A's in vitro cytotoxicity and apoptotic activity were evaluated and myrotheciumone A was shown to exert cytotoxicity via inducing apoptosis in cancer cell line.

摘要

两种新的双环内酯，myrotheciumones A（1）和 B（2），具有罕见的环融合系统，从内生真菌 Myrothecium roridum（M. roridum）中分离出来，该内生真菌是药用植物 Ajuga decumbens（A. decumbens）的一种，通过体外细胞毒性测定。结构是从 1D 和 2D NMR（核磁共振）数据推断出来的。对 myrotheciumone A 的体外细胞毒性和凋亡活性进行了评价，结果表明 myrotheciumone A 通过诱导癌细胞凋亡发挥细胞毒性作用。