Department of Vascular Surgery, Affiliated Hospital of Southwest Medical University, Luzhou, China.
Department of Interventional Medicine, Affiliated Hospital of Southwest Medical University, Luzhou, China.
Int Wound J. 2024 Apr;21(4):e14758. doi: 10.1111/iwj.14758.
A meta-analysis was conducted to comprehensively explore the effects of platelet-rich plasma (PRP) combined with negative pressure wound therapy (NPWT) in treating patients with chronic wounds. Computer searches were conducted, from database infection to November 2023, in EMBASE, Google Scholar, Cochrane Library, PubMed, Wanfang and China National Knowledge Infrastructure databases for randomized controlled trials (RCTs) on the use of PRP combined with NPWT technology for treating chronic wounds. Two researchers independently screened the literature, extracted data and conducted quality assessments according to the inclusion and exclusion criteria. Stata 17.0 software was employed for data analysis. Overall, 18 RCTs involving 1294 patients with chronic wounds were included. The analysis revealed that, compared with NPWT alone, the use of PRP combined with NPWT technology significantly improved the healing rate (odds ratios [OR] = 1.92, 95% confidence intervals [CIs]: 1.43-2.58, p < 0.001) and total effective rate (OR = 1.31, 95% CI: 1.23-1.39, p < 0.001), and also significantly shortened the healing time of the wound (standardized mean difference = -2.01, 95% CI: -2.58 to -1.45, p < 0.001). This study indicates that the treatment of chronic wounds with PRP combined with NPWT technology can significantly enhance clinical repair effectiveness and accelerate wound healing, with a high healing rate, and is worth further promotion and practice.
一项荟萃分析全面探讨了富血小板血浆（PRP）联合负压伤口治疗（NPWT）治疗慢性创面患者的效果。计算机检索 EMBASE、Google Scholar、Cochrane 图书馆、PubMed、万方和中国知网数据库，搜集 PRP 联合 NPWT 技术治疗慢性创面的随机对照试验（RCT），检索时限均从建库至 2023 年 11 月。由 2 位研究者独立筛选文献、提取资料并按照纳入与排除标准进行质量评价后，采用 Stata 17.0 软件进行数据分析。最终纳入 18 项 RCT，共计 1294 例慢性创面患者。分析结果显示，与 NPWT 单独治疗相比，PRP 联合 NPWT 技术可显著提高创面愈合率[比值比（OR）=1.92，95%可信区间（CI）：1.43-2.58，P<0.001]和总有效率（OR=1.31，95%CI：1.23-1.39，P<0.001），同时还显著缩短创面愈合时间[标准化均数差（SMD）=-2.01，95%CI：-2.58 至-1.45，P<0.001]。该研究表明，PRP 联合 NPWT 技术治疗慢性创面能显著提高临床修复效果，加快创面愈合，具有较高的愈合率，值得进一步推广应用。
