2011年至2019年在日本分离出的89株菌株的基因特征分析。
Genetic Characterization of 89 Strains Isolated in Japan From 2011 to 2019.
作者信息
Hirose Yujiro, Yamaguchi Masaya, Takemoto Norihiko, Miyoshi-Akiyama Tohru, Sumitomo Tomoko, Nakata Masanobu, Ikebe Tadayoshi, Hanada Tomoki, Yamaguchi Takahiro, Kawahara Ryuji, Okuno Rumi, Otsuka Hitoshi, Matsumoto Yuko, Terashima Yuji, Kazawa Yu, Nakanishi Noriko, Uchida Kaoru, Akiyama Yumi, Iwabuchi Kaori, Nakagawa Chikara, Yamamoto Kazunari, Nizet Victor, Kawabata Shigetada
机构信息
Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan.
Department of Pediatrics, University of California at San Diego School of Medicine, La Jolla, CA, USA.
出版信息
Infect Microbes Dis. 2020 Oct 21;2(4):160-166. doi: 10.1097/IM9.0000000000000038. eCollection 2020 Dec.
Invasive infection caused by 89 strains has been increasing in several countries linked to a recently emergent clade of 89 strains, designated clade 3. In Japan, the features of 89 strains, such as clade classification, remains unknown. In this study, we collected 89 strains isolated from both streptococcal toxic shock syndrome (STSS) (89 STSS isolates) and noninvasive infections (72 non-STSS isolates) in Japan from 2011 to 2019, and conducted whole-genome sequencing and comparative analysis, which resulted in classification of a large majority into clade 3 regardless of disease severity. In addition, invasive disease-associated factors were found among 89 strains, including mutations of control of virulence sensor, and absence of the gene encoding hyaluronidase. These findings provide new insights into genetic features of 89 strains.
由89型菌株引起的侵袭性感染在几个国家呈上升趋势，这与最近出现的89型菌株进化枝（称为进化枝3）有关。在日本，89型菌株的特征，如进化枝分类，仍不清楚。在本研究中，我们收集了2011年至2019年在日本从链球菌中毒性休克综合征（STSS）（89株STSS分离株）和非侵袭性感染（72株非STSS分离株）中分离出的89型菌株，并进行了全基因组测序和比较分析，结果发现无论疾病严重程度如何，绝大多数菌株都属于进化枝3。此外，在89型菌株中发现了与侵袭性疾病相关的因素，包括毒力传感器控制的突变以及编码透明质酸酶的基因缺失。这些发现为89型菌株的遗传特征提供了新的见解。
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