Graduate School of Medicine, Osaka University, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan.
Eur J Cell Biol. 2024 Jun;103(2):151413. doi: 10.1016/j.ejcb.2024.151413. Epub 2024 Apr 12.
A wide variety of transmembrane signals are transduced by cell-surface receptors that activate intracellular signaling molecules. In particular, receptor clustering in the plasma membrane plays a critical role in these processes. Single-spanning or single-pass transmembrane proteins are among the most significant types of membrane receptors, which include adhesion receptors, such as integrins, CD44, cadherins, and receptor tyrosine kinases. Elucidating the molecular mechanisms underlying the regulation of the activity of these receptors is of great significance. Liquid-liquid phase separation (LLPS) is a recently emerging paradigm in cellular physiology for the ubiquitous regulation of the spatiotemporal dynamics of various signaling pathways. This study describes the emerging features of transmembrane signaling through single-spanning receptors from the perspective of phase separation. Possible physicochemical modulations of LLPS-based transmembrane signaling are also discussed.
细胞膜受体可以转导多种跨膜信号，从而激活细胞内的信号分子。特别是，质膜中的受体聚集在这些过程中起着关键作用。单跨膜或单次跨膜蛋白是最重要的膜受体类型之一，其中包括黏附受体，如整合素、CD44、钙黏蛋白和受体酪氨酸激酶。阐明这些受体活性调节的分子机制具有重要意义。液-液相分离（LLPS）是细胞生理学中的一个新出现的范例，可普遍调节各种信号通路的时空动态。本研究从相分离的角度描述了单跨膜受体介导的跨膜信号传递的新特征。还讨论了基于 LLPS 的跨膜信号的可能物理化学调节。
