近膜区对跨膜信号传导的作用。
Juxtamembrane contribution to transmembrane signaling.
作者信息
Deng Wei, Li Renhao
机构信息
Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Emory University School of Medicine, Atlanta, GA, 30322.
出版信息
Biopolymers. 2015 Jul;104(4):317-22. doi: 10.1002/bip.22651.
Abstract
Signaling across the cell membrane mediated by transmembrane receptors plays an important role in diverse biological processes. Recent studies have indicated that, in a number of single-span transmembrane receptors, the intracellular juxtamembrane (JM) sequence linking the transmembrane helix with the rest of the cytoplasmic domain participates directly in the signaling process via several novel mechanisms. This review briefly highlights several modes of JM dynamics in the context of signal transduction that are shared by different types of transmembrane receptors.
摘要
由跨膜受体介导的跨细胞膜信号传导在多种生物学过程中发挥着重要作用。最近的研究表明，在许多单跨膜受体中，连接跨膜螺旋与细胞质结构域其余部分的细胞内近膜（JM）序列通过几种新机制直接参与信号传导过程。本综述简要介绍了不同类型跨膜受体在信号转导过程中共享的几种JM动态模式。
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