The First Hospital of China Medical University, Shenyang, Liaoning, China.
The First Hospital of China Medical University, Shenyang, Liaoning, China
BMJ Open. 2024 Apr 17;14(4):e078934. doi: 10.1136/bmjopen-2023-078934.
Breast cancer stands as the most prevalent type of cancer affecting women globally, and chemotherapy plays a pivotal role in its treatment by diminishing tumour recurrence and enhancing the survival rates of patients. However, chemotherapy-related cognitive impairment (CRCI) often occurs in patients undergoing treatment. Although multiple clinical trials have indicated that exercise therapy can improve CRCI in patients with breast cancer, there are variations in the types of exercise interventions and their effectiveness. We aim to perform a pioneering network meta-analysis (NMA) to assess and prioritise the effectiveness of various exercise interventions in enhancing cognitive function in patients with breast cancer undergoing chemotherapy.
We will search multiple databases, including PubMed, Web of Science, Cochrane, Embase, China National Knowledge Infrastructure, VIP Database for Chinese Technical Periodicals, Wanfang and Sinomed databases, from their inception to May 2023. The main outcome is the cognitive function changes in patients with breast cancer, including subjective and objective results. We will specifically include randomised controlled trials reported in English and Chinese languages, whose primary outcome consists of an assessment of the cognitive function of patients with breast cancer using standardised and validated assessment tools, encompassing both subjective and objective outcomes. The quality of all the trials included will be evaluated based on 'Version 2 of the Cochrane tool for assessing the risk of bias in randomized controlled trials (RoB2)'. We will conduct a Bayesian NMA to thoroughly evaluate and compare the effectiveness of different exercise interventions. We will use cumulative ranking probability plots to estimate the ranking of the best interventions for various exercises. Network plots and funnel plots will be employed to display the study sizes and participants of each exercise intervention, as well as potential publication biases.
The study findings will be shared via peer-reviewed journals to ensure the highest quality and credibility of the research. As the reporting will not include any private patient data, there are no ethical considerations associated with this protocol.
CRD42023406597.
乳腺癌是全球女性最常见的癌症类型，化疗在治疗乳腺癌中起着关键作用，可降低肿瘤复发率并提高患者生存率。然而，化疗相关认知障碍（CRCI）在接受治疗的患者中经常发生。尽管多项临床试验表明运动疗法可以改善乳腺癌患者的 CRCI，但运动干预的类型及其效果存在差异。我们旨在进行一项开创性的网络荟萃分析（NMA），以评估和优先考虑各种运动干预措施在提高接受化疗的乳腺癌患者认知功能方面的有效性。
我们将从多个数据库中进行搜索，包括 PubMed、Web of Science、Cochrane、Embase、中国国家知识基础设施、维普数据库、万方数据库和中国生物医学文献数据库，检索时间从数据库建立至 2023 年 5 月。主要结局是乳腺癌患者认知功能的变化，包括主观和客观结果。我们将特别纳入以英语和中文发表的随机对照试验，其主要结局是使用标准化和验证的评估工具评估乳腺癌患者的认知功能，包括主观和客观结果。所有纳入试验的质量将根据“Cochrane 工具评估随机对照试验偏倚风险（RoB2）版本 2”进行评估。我们将进行贝叶斯 NMA 以全面评估和比较不同运动干预的有效性。我们将使用累积排序概率图来估计各种运动干预的最佳干预措施的排名。网络图和漏斗图将用于显示每个运动干预的研究规模和参与者，以及潜在的发表偏倚。
研究结果将通过同行评审期刊共享，以确保研究的最高质量和可信度。由于报告不包括任何私人患者数据，因此本方案没有伦理考虑。
PROSPERO 注册号：CRD42023406597。
