Angiology Department, Lausanne University Hospital (CHUV), University of Lausanne (UNIL), Switzerland, Lausanne, Switzerland
Angiology Department, Lausanne University Hospital (CHUV), University of Lausanne (UNIL), Switzerland, Lausanne, Switzerland.
BMJ Open. 2024 Apr 17;14(4):e081883. doi: 10.1136/bmjopen-2023-081883.
Supervised exercise training is among the first-line therapies for patients with peripheral artery disease (PAD). Current recommendations for exercise include guidance focusing on claudication pain, programme and session duration, and frequency. However, no guidance is offered regarding exercise training intensity. This study aims to compare the effects of 12-week-long supervised walking exercise training (high-intensity interval training (HIIT) vs moderate-intensity exercise (MOD)) in patients with chronic symptomatic PAD.
This study is a monocentric, interventional, non-blinded randomised controlled trial. 60 patients (30 in each group) will be randomly allocated (by using the random permuted blocks) to 12 weeks (three times a week) of HIIT or MOD. For HIIT, exercise sessions will consist of alternating brief high-intensity (≥85% of the peak heart rate (HR)) periods (≤60 s) of work with periods of passive rest. Patients will be asked to complete 1 and then 2 sets of 5-7 (progressing to 10-15×60 s) walking intervals. For the MOD group, exercise training sessions will consist of an alternation of periods of work performed at moderate intensity (≤76% HR) and periods of passive rest. Interventions will be matched by training load. The primary outcome will be the maximal walking distance. Secondary outcomes will include functional performance, functional capacity, heath-related quality of life, self-perceived walking abilities, physical activity and haemodynamic parameters.
The Angiof-HIIT Study was approved by the Human Research Ethics Committee of the Canton de Vaud (study number: 2022-01752). Written consent is mandatory prior to enrolment and randomisation. The results will be disseminated via national and international scientific meetings, scientific peer-reviewed journals and social media.
NCT05612945.
监督下的运动训练是外周动脉疾病（PAD）患者的一线治疗方法之一。目前对于运动的建议包括对跛行疼痛、方案和疗程以及频率的指导。然而，对于运动训练强度并没有提供任何指导。本研究旨在比较 12 周监督步行运动训练（高强度间歇训练（HIIT）与中等强度运动（MOD））对慢性有症状 PAD 患者的效果。
这是一项单中心、干预性、非盲随机对照试验。将 60 名患者（每组 30 名）随机分配（使用随机排列块）接受 12 周（每周三次）的 HIIT 或 MOD。对于 HIIT，运动课程将包括交替短暂的高强度（≥峰值心率（HR）的 85%）时期（≤60 秒）的工作和被动休息期。患者将被要求完成 1 组，然后完成 2 组 5-7 个（逐渐增加到 10-15×60 秒）的步行间隔。对于 MOD 组，运动训练课程将包括在中等强度（≤HR 的 76%）和被动休息期之间交替进行工作。干预措施将通过训练负荷进行匹配。主要结局将是最大步行距离。次要结局将包括功能表现、功能能力、健康相关生活质量、自我感知的步行能力、身体活动和血液动力学参数。
Angiof-HIIT 研究已获得沃州人类研究伦理委员会的批准（研究编号：2022-01752）。在登记和随机分组之前，必须获得书面同意。结果将通过全国和国际科学会议、科学同行评议期刊和社交媒体进行传播。
NCT05612945。
