牛地方性白血病牛中单克隆 B 细胞增殖，两个整合位点为牛白血病病毒前病毒 DNA。
Monoclonal proliferation of B-cells with two integration sites of bovine leukemia virus proviral DNA in cattle with enzootic bovine leukosis.
机构信息
Laboratory of OSG Veterinary Science for Global Disease Management, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
Department of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido, Japan.
出版信息
J Vet Med Sci. 2024 Jun 1;86(6):653-655. doi: 10.1292/jvms.24-0037. Epub 2024 Apr 16.
The present study analyzed B-cell clonality and bovine leukemia virus (BLV) provirus integration sites in cattle with enzootic bovine leukosis (EBL) having BLV proviral copy numbers less or greater than the number of bovine nucleated cells. EBL cattle with BLV copy numbers less than the number of bovine nucleated cells showed monoclonal and biclonal proliferation of B-cells with one BLV provirus integration site. On the other hand, EBL cattle with BLV copy numbers greater than the number of bovine nucleated cells showed monoclonal proliferation of B-cells with two BLV provirus integration sites. These results suggest that superinfection of BLV can occur in EBL cattle.
本研究分析了患有地方性牛白血病（EBL）且 BLV 前病毒拷贝数低于或高于牛有核细胞数的牛的 B 细胞克隆性和牛白血病病毒（BLV）前病毒整合位点。BLV 前病毒拷贝数低于牛有核细胞数的 EBL 牛的 B 细胞呈单克隆和双克隆增殖，且有一个 BLV 前病毒整合位点。另一方面，BLV 前病毒拷贝数高于牛有核细胞数的 EBL 牛的 B 细胞呈单克隆增殖，有两个 BLV 前病毒整合位点。这些结果表明，BLV 的超感染可能发生在 EBL 牛中。
Zotero 插件