Melcher Johannes, Dierolf Martin, Günther Benedikt, Achterhold Klaus, Pfeiffer Daniela, Pfeiffer Franz
Chair of Biomedical Physics, Physics Department, TUM School of Natural Sciences, Technical University of Munich, 85748 Garching, Germany; Munich Institute of Biomedical Engineering, Technical University of Munich, Boltzmannstr. 11, 85748 Garching, Germany.
Chair of Biomedical Physics, Physics Department, TUM School of Natural Sciences, Technical University of Munich, 85748 Garching, Germany; Munich Institute of Biomedical Engineering, Technical University of Munich, Boltzmannstr. 11, 85748 Garching, Germany.
Z Med Phys. 2024 Apr 15. doi: 10.1016/j.zemedi.2024.03.003.
X-ray diffraction (XRD) is an important material analysis technique with a widespread use of laboratory systems. These systems typically operate at low X-ray energies (from 5 keV to 22 keV) since they rely on the small bandwidth of K-lines like copper. The narrow bandwidth is essential for precise measurements of the crystal structure in these systems. Inverse Compton X-ray source (ICS) could pave the way to XRD at high X-ray energies in a laboratory setting since these sources provide brilliant energy-tunable and partially coherent X-rays. This study demonstrates high-energy XRD at an ICS with strongly absorbing mineralogical samples embedded in soft tissue. A quantitative comparison of the measured XRD patterns with calculations of their expected shapes validates the performance of ICSs for XRD. This analysis was performed for two types of kidney stones of different materials. Since these stones are not isolated in a human body, the influence of the surrounding soft tissue on the XRD pattern is investigated and a correction for this soft tissue contribution is introduced.
X射线衍射（XRD）是一种重要的材料分析技术，在实验室系统中广泛应用。这些系统通常在低X射线能量（5 keV至22 keV）下运行，因为它们依赖于像铜这样的K线的小带宽。窄带宽对于这些系统中晶体结构的精确测量至关重要。逆康普顿X射线源（ICS）可以为在实验室环境中进行高X射线能量的XRD铺平道路，因为这些源提供了明亮的能量可调且部分相干的X射线。本研究展示了在一个ICS上对嵌入软组织中的强吸收矿物学样品进行的高能XRD。将测量的XRD图谱与其预期形状的计算进行定量比较，验证了ICS用于XRD的性能。对两种不同材料的肾结石进行了这种分析。由于这些结石并非孤立于人体中，因此研究了周围软组织对XRD图谱的影响，并引入了对这种软组织贡献的校正。
