The First Clinical College of Chinese Medicine, Hunan University of Chinese Medicine, Changsha 410208, Hunan Province, China.
The First Clinical College of Chinese Medicine, Hunan University of Chinese Medicine, Changsha 410208, Hunan Province, China; Hunan Provincial Key Laboratory of Translational Research in Traditional Chinese Medicine Prescriptions and Zheng, Changsha 410208, Hunan Province, China.
J Integr Med. 2024 May;22(3):210-222. doi: 10.1016/j.joim.2024.03.010. Epub 2024 Mar 28.
In recent years, preclinical research on diabetic kidney disease (DKD) has surged to the forefront of scientific and clinical attention. DKD has become a pervasive complication of type 2 diabetes. Given the complexity of its etiology and pathological mechanisms, current interventions, including drugs, dietary modifications, exercise, hypoglycemic treatments and lipid-lowering methods, often fall short in achieving desired therapeutic outcomes. Iridoids, primarily derived from the potent components of traditional herbs, have been the subject of long-standing research. Preclinical data suggest that iridoids possess notable renal protective properties; however, there has been no summary of the research on their efficacy in the management and treatment of DKD. This article consolidates findings from in vivo and in vitro research on iridoids in the context of DKD and highlights their shared anti-inflammatory activities in treating this condition. Additionally, it explores how certain iridoid components modify their chemical structures through the regulation of intestinal flora, potentially bolstering their therapeutic effects. This review provides a focused examination of the mechanisms through which iridoids may prevent or treat DKD, offering valuable insights for future research endeavors. Please cite this article as: Zhou TY, Tian N, Li L, Yu R. Iridoids modulate inflammation in diabetic kidney disease: A review. J Integr Med. 2024; 22(3): 210-222.
近年来，糖尿病肾病（DKD）的临床前研究成为科学和临床关注的焦点。DKD 已成为 2 型糖尿病的一种普遍并发症。鉴于其病因和病理机制的复杂性，目前的干预措施，包括药物、饮食改变、运动、降血糖治疗和降脂方法，往往无法达到预期的治疗效果。环烯醚萜类化合物主要来源于传统草药中的有效成分，一直是长期研究的主题。临床前数据表明，环烯醚萜类化合物具有显著的肾脏保护特性；然而，目前还没有对其在 DKD 管理和治疗中的疗效的研究进行总结。本文综合了 DKD 中环烯醚萜类化合物的体内和体外研究结果，强调了它们在治疗该疾病中的共同抗炎作用。此外，还探讨了某些环烯醚萜类成分如何通过调节肠道菌群来改变其化学结构，从而可能增强其治疗效果。本综述重点探讨了环烯醚萜类化合物预防或治疗 DKD 的机制，为未来的研究工作提供了有价值的见解。请引用本文作为：Zhou TY, Tian N, Li L, Yu R. Iridoids modulate inflammation in diabetic kidney disease: A review. J Integr Med. 2024; 22(3): 210-222.
