星形胶质细胞与慢性神经炎症有关。

Astrocytes ACLYmate to chronic neuroinflammation.

机构信息

University of Toronto, Department of Immunology, 1 King's College Circle, Toronto, ON M5S 1A8, Canada.

出版信息

Trends Immunol. 2024 May;45(5):320-321. doi: 10.1016/j.it.2024.04.003. Epub 2024 Apr 16.

DOI:10.1016/j.it.2024.04.003

PMID:38632002

Abstract

Astrocytes are essential cells of the mammalian central nervous system (CNS), with key roles in development, homeostasis, and disease. Lee and colleagues recently showed that astrocytes can develop epigenetic memory, which enhances proinflammatory responses to subsequent stimulation, potentially driving sustained neurological disease pathology, such as in multiple sclerosis (MS).

摘要

星形胶质细胞是哺乳动物中枢神经系统 (CNS) 的重要细胞，在发育、稳态和疾病中发挥关键作用。Lee 及其同事最近表明，星形胶质细胞可以形成表观遗传记忆，从而增强对后续刺激的促炎反应，可能导致持续的神经疾病病理学，如多发性硬化症 (MS)。