Pediatric Department, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Pediatric Department, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Rev Argent Microbiol. 2024 Jul-Sep;56(3):281-286. doi: 10.1016/j.ram.2023.09.002. Epub 2024 Apr 16.
Candida bloodstream infections in children are of special concern in neonatal and pediatric intensive care and patients with comorbidities. This study aimed to estimate the incidence and risk factors associated with mortality in candidemia cases occurring in a public children's hospital in Ribeirao Preto, Brazil. It is a retrospective transversal study. Every patient under the age of 18 admitted to the study facility from January 1, 2013, to December 31, 2019, was considered potentially eligible to be included if they had candidemia. We collected clinical data from medical records. We included 113 blood cultures yielding positive results for Candida. The incidence rate was 2.12 per 1000 admissions. The most common Candida species was Candida parapsilosis. Septic shock during the candidemia episode was the only clinical outcome associated with a relative risk-adjusted (RRa) of 2.77 with an interval >1 (1.12-6.85). Our findings show that the incidence rate and mortality rates of candidemia are in line with those in other children's services in Brazil. We found a global mortality rate of 28.31% (32/113) from candidemia episodes. We highlight the predominance of non-albicans Candida species including C. parapsilosis. Septic shock was the most important factor showing a significant risk of mortality.
儿童念珠菌血流感染在新生儿和儿科重症监护病房以及合并症患者中尤为令人关注。本研究旨在评估巴西里贝朗普雷图市一家公立儿童医院发生的念珠菌血症病例的发病率和与死亡率相关的危险因素。这是一项回顾性的横断面研究。2013 年 1 月 1 日至 2019 年 12 月 31 日期间，凡年龄在 18 岁以下、入住研究机构的患者，如果有念珠菌血症，均被视为可能有资格入选。我们从病历中收集了临床数据。我们共纳入了 113 例血液培养阳性的念珠菌血症病例。发病率为每 1000 例住院患者中有 2.12 例。最常见的念珠菌菌种是近平滑念珠菌。念珠菌血症发作期间发生感染性休克是唯一与相对风险调整（RRa）值为 2.77（1.12-6.85）相关的临床结局。我们的研究结果表明，念珠菌血症的发病率和死亡率与巴西其他儿科服务机构一致。我们发现，113 例念珠菌血症患者的总体死亡率为 28.31%（32/113）。我们强调了非白念珠菌念珠菌菌种的流行，包括近平滑念珠菌。感染性休克是显示出显著死亡风险的最重要因素。
