Eguileor Beatriz de Luis, Zorrozúa Borja Santos, Ecenarro Jaime Etxebarria
Deparment of Ophthalmology, BioCruces Bizkaia Health Research Institute, Cruces University Hospital, Barakaldo, Spain.
Scientific Coordination Unit, Biocruces Bizkaia Health Research Institute, Cruces University Hospital, Osakidetza, Bilbao, Basque Country, Spain.
Eur J Ophthalmol. 2024 Jul;34(4):973-979. doi: 10.1177/11206721241247587. Epub 2024 Apr 18.
To establish new criteria for the progression of keratoconus, taking into account a Pentacam HR (high resolution) tomographeŕs repeatability limit.
This is a retrospective observational study, including 224 eyes in 154 patients diagnosed with keratoconus and patients treated with crosslinking, with a follow-up of at least one year, in which the new progression score of the Cruces University Hospital for keratoconus progression was analyzed. This score takes into account: maximum keratometry, thinnest corneal thickness, maximum posterior elevation, vertical coma and RMS of high order aberrations, all based on the tomographer repeatability limit. The effectiveness or not of crosslinking was determined.
The Receiver Operating Characteristics (ROC) curves obtained in our validation met the criteria by being far from the reference diagonal. Moreover, young patients are more likely to have keratoconus that progresses, and the percentage of patients that showed progression was 14.3% of the eyes studied, with the most advanced keratoconus showing the least progression. Taking into account the new progression score of the Cruces Hospital, we would have indicated crosslinking in 2 eyes only and we observed that none progressed one year after treatment.
The the new progression score of the Cruces University Hospital is a method based on the real repeatability limit for keratoconic eyes. Moreover, it is easy to interpret and can be implemented with Pentacam software. It provides a numerical value that evaluates both the anterior and posterior surfaces of the cornea and corneal aberrations in the evolution of keratoconus.
考虑Pentacam HR(高分辨率)断层扫描仪的重复性极限,建立圆锥角膜进展的新标准。
这是一项回顾性观察研究,纳入了154例诊断为圆锥角膜且接受交联治疗的患者的224只眼睛,随访至少一年,分析了克鲁塞斯大学医院圆锥角膜进展的新进展评分。该评分考虑了:最大角膜曲率、最薄角膜厚度、最大后表面抬高、垂直彗差和高阶像差的均方根,所有这些均基于断层扫描仪的重复性极限。确定了交联的有效性。
我们验证中获得的受试者工作特征(ROC)曲线符合标准,远离参考对角线。此外,年轻患者的圆锥角膜更易进展,在所研究的眼睛中,显示进展的患者比例为14.3%,圆锥角膜最严重的患者进展最少。考虑到克鲁塞斯医院的新进展评分,我们仅会建议对2只眼睛进行交联,并且我们观察到治疗一年后无一只眼睛进展。
克鲁塞斯大学医院的新进展评分是一种基于圆锥角膜眼睛实际重复性极限的方法。此外,它易于解读,可通过Pentacam软件实施。它提供了一个数值,用于评估圆锥角膜进展过程中角膜的前表面和后表面以及角膜像差。