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Epidemiology of Chronic Hepatitis B in Turkey.土耳其慢性乙型肝炎的流行病学
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将乙肝疫苗引入常规婴儿免疫规划20年后锡尔纳克地区乙肝表面抗原（HBsAg）和乙肝表面抗体（抗-HBs）的变化率

Change in Rates of HBsAg and Anti-HBs in Şırnak 20 Years After Introduction of Hepatitis B Vaccine into Routine Infant Immunization Program.

作者信息

Şahin Meyha, Yazla Meltem

机构信息

Clinic of Infectious Diseases and Clinical Microbiology, İstanbul Medipol University Medipol Mega Hospital, İstanbul, Turkey.

Clinic of Infectious Diseases and Clinical Microbiology, University of Health Sciences Bakırköy Dr. Sadi Konuk Training and Research Hospital, İstanbul, Turkey.

出版信息

Infect Dis Clin Microbiol. 2023 Jun 23;5(2):153-157. doi: 10.36519/idcm.2023.231. eCollection 2023 Jun.

DOI:10.36519/idcm.2023.231
PMID:38633007
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10986700/
Abstract

OBJECTIVES

This study aimed to monitor the change in the rate of hepatitis B infections in Şırnak, a province in south-eastern Turkey, and to determine the rate of immunization for hepatitis B in this region after the national immunization program covered hepatitis B.

MATERIALS AND METHODS

This retrospective study included patients born in 1998 or after and applied to different outpatient clinics in the province between April 2017 and June 2018. Patients in this study were screened for HBsAg and anti-HBs for various reasons. We analyzed confirmed HBsAg and anti-HBs positive results according to gender, age, and vertical transmission. Anti-HBs-positive patients were divided into four groups according to their ages, and the groups were compared.

RESULTS

Out of 2713 patients, 1530 (56.4%) were male, and the mean age was 12.77 (0-20). Four patients (0.14%) were HBsAg positive, and the anti-HBs positivity rate was 61.22%. The difference was statistically significant when the anti-HBs positivity rate was compared between the age groups (<0.001). The highest anti-HBs positivity rate was found in the 0 to 5 age group.

CONCLUSION

There has been a significant decrease in hepatitis B virus infection rates after introducing the hepatitis B vaccine into routine infant immunization programs. The widespread introduction of hepatitis B vaccination should be targeted in Turkey, considering its geographical and sociocultural diversity.

摘要

目的

本研究旨在监测土耳其东南部省份锡尔纳克的乙肝感染率变化，并确定在国家免疫规划纳入乙肝疫苗后该地区的乙肝免疫接种率。

材料与方法

这项回顾性研究纳入了1998年及以后出生、于2017年4月至2018年6月期间到该省不同门诊就诊的患者。本研究中的患者因各种原因接受了乙肝表面抗原（HBsAg）和乙肝表面抗体（抗-HBs）筛查。我们根据性别、年龄和垂直传播情况分析了确诊的HBsAg和抗-HBs阳性结果。抗-HBs阳性患者按年龄分为四组，并对各组进行比较。

结果

在2713名患者中，1530名（56.4%）为男性，平均年龄为12.77岁（0 - 20岁）。4名患者（0.14%）HBsAg呈阳性，抗-HBs阳性率为61.22%。各年龄组抗-HBs阳性率比较差异有统计学意义（<0.001）。抗-HBs阳性率最高的是0至5岁年龄组。

结论

将乙肝疫苗纳入常规婴儿免疫规划后，乙肝病毒感染率显著下降。考虑到土耳其的地理和社会文化多样性，应针对性地广泛推广乙肝疫苗接种。