Department of Pharmacology, Sri Devaraj Urs Medical College, Sri Devaraj Urs Academy of Higher Education and Research, Tamaka, Kolar, Karnataka, India.
Department of Microbiology, Sri Devaraj Urs Medical College, Sri Devaraj Urs Academy of Higher Education and Research, Tamaka, Kolar, Karnataka, India.
Biomed Res Int. 2017;2017:1327492. doi: 10.1155/2017/1327492. Epub 2017 Sep 26.
Hepatitis B is one of the most important occupational hazards among healthcare workers (HCWs). This study aimed to measure the anti-HBs titres among the medical students and HCWs vaccinated against hepatitis B virus and to determine the association between anti-HBs levels and time since vaccination.
In this cross-sectional study, medical students and healthcare workers who had received all three doses of hepatitis B vaccination and completed at least six months after vaccination since the last dose were included. 3 ml blood was collected from subjects ( = 340) and anti-HBs titre was estimated using ELISA.
A total of 340/400 subjects were aged between 18 and 60 years; 204 were females and 136 males. The median and interquartile range for time since vaccination were 5 and 5 years, respectively. Duration since vaccination was ≤5 years in 223 (65.5%), 6-10 years in 84 (24.7%), and >10 years in 33 (9.70%); among them, antibody titres were >10 mIU/ml in 94.1%, 79.7%, and 72.7% subjects, respectively. There was significant decline in antibody titres as duration of postvaccination increased.
The proportion of subjects who were unprotected after 5 and 10 years after vaccination were 20% and 27%, respectively. The need for a booster dose can be made mandatory at least for healthcare professionals.
乙型肝炎是医护人员（HCWs）最重要的职业危害之一。本研究旨在测量接种乙型肝炎病毒疫苗的医学生和 HCWs 的抗-HBs 滴度，并确定抗-HBs 水平与接种后时间之间的关系。
在这项横断面研究中，纳入了已接种全部三剂乙型肝炎疫苗且最后一剂接种后至少六个月的医学生和医护人员。从受试者中采集 3ml 血液（n=340），并使用 ELISA 估计抗-HBs 滴度。
共有 340/400 名受试者年龄在 18 至 60 岁之间；204 名女性，136 名男性。接种后时间的中位数和四分位距分别为 5 年和 5 年。223 名（65.5%）受试者接种后时间≤5 年，84 名（24.7%）接种后时间 6-10 年，33 名（9.70%）接种后时间>10 年；其中，抗体滴度>10mIU/ml 的受试者比例分别为 94.1%、79.7%和 72.7%。随着接种后时间的增加，抗体滴度显著下降。
接种后 5 年和 10 年后未受保护的受试者比例分别为 20%和 27%。至少应强制要求医护人员接种加强剂量。
