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丁香提取物对亚硝酸钠诱导的大鼠睾丸损伤的改善作用。

Ameliorative effect of extract against testicular damage induced by sodium nitrite in rats.

机构信息

Department of Biochemistry, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh, Egypt.

Department of Theriogenology, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh, Egypt.

出版信息

Open Vet J. 2024 Jan;14(1):304-315. doi: 10.5455/OVJ.2024.v14.i1.27. Epub 2024 Jan 31.

DOI:10.5455/OVJ.2024.v14.i1.27
PMID:38633197
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11018448/
Abstract

BACKGROUND

Sodium nitrite (NaNO) is a chemical substance used to enhance taste, add color, and keep food products fit for consumption for a longer time. NaNO gives rise to a negative adverse effect on male reproductive function. (OC) is a natural plant that possesses antioxidant capacity.

AIM

Our research evaluates the potential beneficial effect of OC extract on the harmful effects caused by NaNO on the testicular tissue and sperm characteristics of male rats.

METHODS

Four groups with a total of forty rats: the control, the NaNO-received group, the OC-administered group, and the fourth group received both NaNO and OC. All groups were administered daily for two months. Sperm characteristics, testicular antioxidant status, qRT-PCR, and histopathological changes were evaluated.

RESULTS

Coadministration of NaNO and OC, in comparison with NaNO alone, contributed to a notable enhancement in acrosomal integrity, decreasing sperm abnormalities and restoring serum testosterone levels. Moreover, such coadministration reduced the oxidative stress marker, malondialdehyde (MDA), and increased superoxide dismutase (SOD) in testicular tissue, lowering TNF-α gene expression, and increasing the expression of P450scc and StAR genes. In addition, the NaNO and OC combination decreased the testicular histopathological changes and the Caspase-3 and Proliferating cell nuclear antigen (PCNA) immunoexpression in seminiferous tubules compared with the NaNO group.

CONCLUSION

The extract of OC exhibited the ability to decrease oxidative stress and ameliorate the detrimental effects caused by NaNO.

摘要

背景

亚硝酸钠（NaNO）是一种用于增强味道、添加颜色并使食品保持更长时间可食用的化学物质。NaNO 对男性生殖功能产生负面影响。（OC）是一种具有抗氧化能力的天然植物。

目的

我们的研究评估 OC 提取物对 NaNO 对雄性大鼠睾丸组织和精子特性的有害影响的潜在有益作用。

方法

共有 40 只大鼠分为 4 组：对照组、NaNO 组、OC 组和第 4 组同时接受 NaNO 和 OC。所有组均连续两个月每天给药。评估精子特性、睾丸抗氧化状态、qRT-PCR 和组织病理学变化。

结果

与单独使用 NaNO 相比，同时给予 NaNO 和 OC 有助于显著提高顶体完整性，减少精子异常并恢复血清睾酮水平。此外，这种联合使用降低了睾丸组织中的氧化应激标志物丙二醛（MDA），增加了超氧化物歧化酶（SOD），降低了 TNF-α 基因表达，并增加了 P450scc 和 StAR 基因的表达。此外，与 NaNO 组相比，NaNO 和 OC 联合使用降低了睾丸组织的组织病理学变化和 Caspase-3 和增殖细胞核抗原（PCNA）在生精小管中的免疫表达。

结论

OC 提取物具有降低氧化应激和改善 NaNO 引起的有害作用的能力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69d8/11018448/4df0006f69e9/OpenVetJ-14-304-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69d8/11018448/c5e5ee8bfe9d/OpenVetJ-14-304-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69d8/11018448/28b220d47cc0/OpenVetJ-14-304-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69d8/11018448/d19533d1a5ab/OpenVetJ-14-304-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69d8/11018448/0d314a0fb80d/OpenVetJ-14-304-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69d8/11018448/4df0006f69e9/OpenVetJ-14-304-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69d8/11018448/c5e5ee8bfe9d/OpenVetJ-14-304-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69d8/11018448/28b220d47cc0/OpenVetJ-14-304-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69d8/11018448/d19533d1a5ab/OpenVetJ-14-304-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69d8/11018448/0d314a0fb80d/OpenVetJ-14-304-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69d8/11018448/4df0006f69e9/OpenVetJ-14-304-g005.jpg

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