Anklesaria P N, Advani S H, Bhisey A N
Tumori. 1985 Aug 31;71(4):317-23. doi: 10.1177/030089168507100401.
Granulocyte functions, viz. endocytosis, NADPH oxidase activity and iodination by leukocytes, were studied in granulocytes isolated from 17 chronic myeloid leukemia (CML) patients at initial diagnosis (stage I), from 10 patients in relapse (stage II), and 10 patients in acute blastic crisis (stage III). The mean phagocytic index of granulocytes from CML patients was similar to the normal value. NADPH activity decreased as the disease progressed. Thus, the amount of formazan produced was lower in granulocytes from patients in stage II (P less than 0.05) and stage III (P less than 0.01) than that produced by normal granulocytes. H2O2-Myeloperoxidase-dependent iodination was found to be significantly reduced in granulocytes from all stages of the disease compared to that of normal, stage I (P less than 0.01), stage II (P less than 0.05) and stage III (P less than 0.01). It thus seems that granulocyte function becomes less efficient as the disease progresses towards acute blastic crisis. Immature cells from the same patients carried out these functions at a more reduced level than did their mature counterparts.
对17例初诊（I期）慢性髓性白血病（CML）患者、10例复发患者（II期）和10例急性原始细胞危象患者（III期）分离出的粒细胞的功能，即内吞作用、NADPH氧化酶活性和白细胞碘化作用进行了研究。CML患者粒细胞的平均吞噬指数与正常值相似。随着疾病进展，NADPH活性降低。因此，II期（P<0.05）和III期（P<0.01）患者粒细胞产生的甲臜量低于正常粒细胞产生的量。与正常情况相比，I期（P<0.01）、II期（P<0.05）和III期（P<0.01）疾病各阶段患者粒细胞中H2O2-髓过氧化物酶依赖性碘化作用均显著降低。因此，随着疾病进展至急性原始细胞危象，粒细胞功能似乎变得效率更低。同一患者的未成熟细胞执行这些功能的水平比成熟细胞更低。
