内皮单核细胞抗原由HLA - B着丝粒的基因座编码。

Endothelial monocyte antigens are coded for by loci centromeric of HLA-B.

作者信息

Neppert J, Mueller-Eckhardt G, Stranzenbach W, Göttsche B, Mueller-Eckhardt C

出版信息

Vox Sang. 1985;49(3):221-9. doi: 10.1111/j.1423-0410.1985.tb00797.x.

DOI:10.1111/j.1423-0410.1985.tb00797.x

Abstract

900 pregnancy sera were screened for monocyte antibodies. 23 sera (2.6%) were found to be reactive with monocytes in an allotypic pattern distinct from blood group ABO, HLA-A,B,C, DR and DQ specificities. Because of strong reactions and high reproducibility, 4 sera with pure endothelial monocyte (EM) reactivity and 2 sera also positive with B lymphocytes of certain donors were selected for population and family studies. The frequency of positive reactions in a panel of 26 random donors obtained with the pure EM sera was 13, 8, 8 and 13% with clearly distinct patterns. Analysis of the tentatively designated EM antigens 1.1, 1.2, 2.1, and 2.2 in 7 families revealed definite segregation with HLA. By means of two crossing-over events within the HLA region the two hypothetical EM loci were localized centromeric of HLA-A and one of both loci centromeric of HLA-B.

摘要

对900份孕妇血清进行了单核细胞抗体筛查。发现23份血清（2.6%）与单核细胞发生反应，其异型模式不同于ABO血型、HLA - A、B、C、DR和DQ特异性。由于反应强烈且重复性高，选择了4份具有纯内皮单核细胞（EM）反应性的血清以及2份对某些供体的B淋巴细胞也呈阳性的血清进行群体和家族研究。用纯EM血清在一组26名随机供体中获得的阳性反应频率分别为13%、8%、8%和13%，具有明显不同的模式。对7个家族中初步命名的EM抗原1.1、1.2、2.1和2.2的分析显示与HLA有明确的分离。通过HLA区域内的两次交叉事件，两个假定的EM基因座定位在HLA - A着丝粒侧，两个基因座中的一个定位在HLA - B着丝粒侧。