Tanrıverdi-Çaycı Yeliz, Güne Doğa Beliz, Ertokatlı Mustafa, Hacıeminoğlu-Ülker Kübra, Birinci Asuman
Department of Medical Microbiology, Ondokuz Mayıs University School of Medicine, Samsun, Turkey.
Ondokuz Mayıs University School of Medicine, Samsun, Turkey.
Infect Dis Clin Microbiol. 2022 Dec 21;4(4):252-257. doi: 10.36519/idcm.2022.163. eCollection 2022 Dec.
Urinary tract infections are one of the most common causes of morbidity around the world. Fosfomycin is a specific broad-spectrum antibiotic used to treat these infections. However, in recent years, many studies have reported increased fosfomycin resistance in Enterobacterales isolates. Therefore, this study aimed to evaluate the distribution of pathogens isolated from urine samples and find the fosfomycin resistance rates over nine years (2012-2020).
A total of 18,884 uropathogenic Enterobacterales isolates were included in the study between 2012 and 2020. The isolates were identified by VITEK 2 Compact (bioMérieux, Marcy l'Etoile, France), and the antimicrobial susceptibilities of the isolates were also evaluated using the VITEK MS automated system (bioMérieux, Marcy l'Etoile, France).
(64.04%) was the most common bacteria among Enterobacterales. Fosfomycin resistance rates were 1.98%, 21.64%, and 10.36% in E. coli, , and all bacteria, respectively. The 34.97% of isolates were extended-spectrum β-lactamase (ESBL)-producing Enterobacterales, and the fosfomycin resistance rate was 13.08% in these isolates. In addition, fosfomycin resistance rates were found as 3.06% and 23.84% in ESBL-producing and ESBL-producing , respectively.
Fosfomycin seems a good option for effectively treating UTIs caused by E. coli. On the other hand, we found that fosfomycin resistance tends to increase over the years. Therefore, we recommend further studies to evaluate fosfomycin resistance.
尿路感染是全球发病的最常见原因之一。磷霉素是一种用于治疗这些感染的特异性广谱抗生素。然而，近年来，许多研究报告称肠杆菌科分离株对磷霉素的耐药性有所增加。因此，本研究旨在评估从尿液样本中分离出的病原体分布情况，并找出九年间（2012 - 2020年）磷霉素的耐药率。
2012年至2020年间，共有18884株尿路致病性肠杆菌科分离株纳入本研究。这些分离株通过VITEK 2 Compact（法国生物梅里埃公司，马西伊图瓦勒）进行鉴定，分离株的抗菌药敏性也使用VITEK MS自动化系统（法国生物梅里埃公司，马西伊图瓦勒）进行评估。
（64.04%）是肠杆菌科中最常见的细菌。大肠杆菌、 、所有细菌的磷霉素耐药率分别为1.98%、21.64%和10.36%。34.97%的分离株是产超广谱β-内酰胺酶（ESBL）的肠杆菌科细菌，这些分离株的磷霉素耐药率为13.08%。此外，产ESBL的 和产ESBL的 中磷霉素耐药率分别为3.06%和23.84%。
磷霉素似乎是有效治疗由大肠杆菌引起的尿路感染的一个良好选择。另一方面，我们发现磷霉素耐药性多年来有增加的趋势。因此，我们建议进一步开展研究以评估磷霉素耐药性。
