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免疫功能正常患者发生复发性诺卡菌性脑脓肿:一例报告

Recurrent Nocardial Brain Abscess Developing in an Immunocompetent Patient, A Case Report.

作者信息

Şahin Suzan, Menekşe Şirin

机构信息

Infectious Disease and Clinic Microbiology Department, Kartal Dr. Lütfi Kirdar City Hospital, İstanbul, Turkey.

Infectious Disease and Clinic Microbiology Department, Kartal Koşuyolu Training and Research Hospital, İstanbul, Turkey.

出版信息

Infect Dis Clin Microbiol. 2022 Dec 21;4(4):280-284. doi: 10.36519/idcm.2022.160. eCollection 2022 Dec.

Abstract

Central nervous system nocardiosis is rare but has high morbidity and mortality. Immunocompromised patients who have malignancies such as lymphoma, infections such as human immunodeficiency virus (HIV), and bone marrow or solid organ recipients are particularly vulnerable to infection. However, here, we present a patient who developed nocardiosis and recurrent brain abscesses despite having no immunodeficiency problems. The abscess recurred despite total abscess excision and parenteral therapy. After nocardiosis was diagnosed, intravenous treatment with imipenem and amikacin was initiated. The patient was discharged on oral doxycycline. In our immunocompetent case, the abscess recurred four times, resulting in death.

摘要

中枢神经系统诺卡菌病虽罕见,但发病率和死亡率很高。患有淋巴瘤等恶性肿瘤、人类免疫缺陷病毒(HIV)等感染的免疫功能低下患者,以及骨髓或实体器官移植受者特别容易感染。然而,在此我们报告一名患者,尽管没有免疫缺陷问题,却患上了诺卡菌病并反复发生脑脓肿。尽管脓肿已完全切除并进行了肠外治疗,但脓肿仍复发。诺卡菌病确诊后,开始用亚胺培南和阿米卡星进行静脉治疗。患者出院时口服强力霉素。在我们这个免疫功能正常的病例中,脓肿复发了四次,最终导致患者死亡。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d227/10986689/03352c5c42bc/IDCM-4-4-160_Figure1.jpg

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