Alaswad Marwan, Otry Abdullah Al, Alhosainy Ziad, Elkordy Fadwa, Sabbah Belal Nedal, Arabi Tarek Ziad, Abdulkader Humzah, Ghanayem Obaida Fadi, Azzam Ayman Zaki, Amin Tarek
College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
Department of Surgery, Surgical Oncology, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
Front Oncol. 2024 Apr 3;14:1361017. doi: 10.3389/fonc.2024.1361017. eCollection 2024.
Gallbladder cancer (GBC) is a rare and highly aggressive malignancy, often characterized by nonspecific clinical presentations and late diagnosis, which contribute to its poor prognosis. It is commonly detected at advanced stages, leading to low survival rates. Surgical resection is the primary treatment, with the extent of surgery depending on the T stage of the cancer. In advanced cases, surgery is only considered if it can potentially be curative. Despite various treatment approaches for advanced GBC, survival outcomes remain poor. In our case series, we introduce a novel treatment approach combining cytoreductive surgery, intraoperative radiation therapy, and hyperthermic intraperitoneal chemotherapy. Remarkably, we observed a 100% one-year survival rate, with one patient achieving eight years of disease-free survival without recurrence or metastasis. This aggressive treatment strategy did not lead to increased morbidity or mortality, suggesting its safety and feasibility. However, larger-scale studies are required to draw definitive conclusions.
胆囊癌（GBC）是一种罕见且侵袭性很强的恶性肿瘤，其临床表现通常不具有特异性，且诊断往往较晚，这些因素导致其预后较差。它通常在晚期才被发现，生存率较低。手术切除是主要的治疗方法，手术范围取决于癌症的T分期。在晚期病例中，只有当手术有可能治愈时才会考虑进行。尽管针对晚期胆囊癌有多种治疗方法，但生存结果仍然不佳。在我们的病例系列中，我们介绍了一种新的治疗方法，该方法结合了减瘤手术、术中放射治疗和热灌注腹腔化疗。值得注意的是，我们观察到一年生存率为100%，其中一名患者实现了八年无病生存，且无复发或转移。这种积极的治疗策略并未导致发病率或死亡率增加，表明其安全性和可行性。然而，需要进行更大规模的研究才能得出明确的结论。
