Han Qilin, Li Yifan, Liu Yao, Zhu Xuehan, An Qiqi, Li Yameng, Wang Tingting, Zhang Yuzhen, Li Yingying, Fang Weiwei, Tao Ningning, Li Huaichen
Department of Pulmonary and Critical Care Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, People's Republic of China.
Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, 250117, People's Republic of China.
Infect Drug Resist. 2024 Apr 12;17:1477-1490. doi: 10.2147/IDR.S454076. eCollection 2024.
To analyze the time trends in the notification rates of registered tuberculosis (TB) and bacteriologically confirmed TB in Shandong Province. And analyze the changes in TB treatment outcomes during 2005-2021.
The information of TB patients registered in the Shandong Information Center for Disease Control and Prevention (CDC) was collected during 2005-2021. We calculated the notification rates of registered TB and bacteriologically confirmed TB. Moreover, we calculated the year-to-year change rate of TB in treatment outcomes before and after COVID-19. The time trends were analyzed using the joinpoint regression method and illustrated as the annual percentage change (APC) of notification rates.
A total of 236,898 cases of TB were diagnosed during 2005-2021, of which 51.11% were bacteriologically confirmed cases. Since 2008, the notification rates of registered TB have declined. The notification rates of bacteriologically confirmed TB had been declining during 2005-2016, then remained stable after 2016. In subgroup, the notification rates of both registered TB and bacteriologically confirmed TB were higher among men, rural residents, and people aged ≥ 60 years. Compared with clinically confirmed TB, bacteriologically confirmed TB has shown higher rates of poor outcomes since 2008 and higher case fatality rate since 2005. The rate of poor outcomes remained stable during 2008-2019. However, after the COVID-19 outbreak, the rate of poor outcomes and case fatality rate of TB has risen significantly.
After unremitting efforts to fight against TB, the notification rates of registered TB and bacteriologically confirmed TB declined in Shandong Province. The rate of poor outcomes remained stable during 2008-2019, then rise significantly after the COVID-19 outbreak. In the context of the long-term existence of COVID-19, further efforts should be made in TB diagnosis and treatment among high-risk population, especially with regard to males, rural residents and older adults.
分析山东省登记结核病（TB）和细菌学确诊结核病的报告率的时间趋势。并分析2005 - 2021年期间结核病治疗结果的变化。
收集2005 - 2021年期间山东省疾病预防控制中心信息中心登记的结核病患者信息。我们计算了登记结核病和细菌学确诊结核病的报告率。此外，我们计算了新冠肺炎疫情前后结核病治疗结果的逐年变化率。使用连接点回归方法分析时间趋势，并以报告率的年度百分比变化（APC）表示。
2005 - 2021年期间共诊断出236,898例结核病病例，其中51.11%为细菌学确诊病例。自2008年以来，登记结核病的报告率有所下降。2005 - 2016年期间细菌学确诊结核病的报告率一直在下降，2016年后保持稳定。在亚组中，登记结核病和细菌学确诊结核病的报告率在男性、农村居民和60岁及以上人群中较高。与临床确诊结核病相比，自2008年以来，细菌学确诊结核病的不良结局发生率较高，自2005年以来病死率较高。2008 - 2019年期间不良结局发生率保持稳定。然而，新冠肺炎疫情爆发后，结核病的不良结局发生率和病死率显著上升。
经过抗击结核病的不懈努力，山东省登记结核病和细菌学确诊结核病的报告率有所下降。2008 - 2019年期间不良结局发生率保持稳定，新冠肺炎疫情爆发后显著上升。在新冠肺炎长期存在的背景下，应在高危人群中，特别是男性、农村居民和老年人的结核病诊断和治疗方面进一步努力。
