Saigo P E, Wolinska W H, Kim W S, Hajdu S I
Acta Cytol. 1985 Sep-Oct;29(5):785-94.
A review was undertaken of the 121 patients with cervical adenocarcinoma, ranging in age from 10 to 91 years, who had cytology specimens examined in this laboratory. All but two had cervicovaginal smears. Fifty-eight patients had cervical smears taken prior to treatment; 91% of these contained malignant cells. The commonest histologic subtype was mucinous adenocarcinoma (61 patients; 52%), followed by endometrioid carcinoma (26 cases; 22%), adenosquamous carcinoma (16 cases; 14%) and clear-cell carcinoma (12 cases; 10%). The cytologic characteristics were evaluated and correlated with the histopathology. During the follow-up period after definitive treatment, 119 patients had gynecologic smears taken; 24% were positive, representing 64% of those cases with central recurrences. In two patients, the abnormal smear was the first indicator of recurrence. Nine patients had 11 nongynecologic specimens revealing metastatic disease. Notable in this study were the 18 asymptomatic women, of whom 15 also had either no visible cervical lesion or minimal changes associated with benign conditions; cytology was abnormal in all but two. Cytology was effective in detecting disease. Its usefulness continued during the follow-up period in identifying or confirming recurrent or metastatic disease.
对本实验室检查过细胞学标本的121例宫颈腺癌患者进行了回顾性研究，这些患者年龄在10至91岁之间。除2例患者外，其余均进行了宫颈阴道涂片检查。58例患者在治疗前进行了宫颈涂片检查，其中91%的涂片含有恶性细胞。最常见的组织学亚型是黏液腺癌（61例，占52%），其次是子宫内膜样癌（26例，占22%）、腺鳞癌（16例，占14%）和透明细胞癌（12例，占10%）。对细胞学特征进行了评估，并与组织病理学进行了关联分析。在确定性治疗后的随访期间，119例患者进行了妇科涂片检查，其中24%的涂片呈阳性，占中心复发患者的64%。在2例患者中，异常涂片是复发的首个指标。9例患者的11份非妇科标本显示有转移疾病。本研究中值得注意的是18例无症状女性，其中15例宫颈无可见病变或仅有与良性情况相关的轻微改变；除2例患者外，其余患者的细胞学检查均异常。细胞学检查在检测疾病方面有效。在随访期间，其在识别或确认复发或转移疾病方面仍然有用。
