Division of Dermatology, Department of Medicine, University of Toronto, Toronto, Canada.
Division of Dermatology, Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, Canada.
Int J Dermatol. 2024 Nov;63(11):1528-1534. doi: 10.1111/ijd.17182. Epub 2024 Apr 18.
Hidradenitis suppurativa (HS) is a systemic disorder associated with various metabolic and inflammatory comorbidities. Although HS shares risk factors and pathogenic pathways with various respiratory conditions, few studies have explored the relationship between HS and respiratory disease.
This is a cross-sectional, case-control, population-based study that examined the United States National Inpatient Sample database from January 1, 2002, to December 31, 2012. HS was identified using ICD-9-CM codes during hospital admissions. Multivariable logistic regression was used to evaluate for adjusted associations between HS and respiratory diagnoses as compared to matched controls.
Twenty-three thousand seven hundred and sixty-seven hospital admissions for HS were compared with 95,068 age- and sex-matched controls. HS patients had significantly higher adjusted odds of asthma (OR: 1.233; 95% CI: [1.170-1.299]; P < 0.001), chronic airway obstruction (OR: 1.532; 95% CI: [1.419-1.651]; P < 0.001), sarcoidosis (OR: 1.601; 95% CI: [1.157-2.214]; P < 0.001), and sleep apnea (OR: 1.274; 95% CI: [1.182-1.374]; P < 0.001).
HS is associated with several common forms of respiratory disease. Knowledge of these associations may allow for better recognition of respiratory disease in HS patients.
化脓性汗腺炎（HS）是一种与多种代谢和炎症合并症相关的系统性疾病。尽管 HS 与各种呼吸系统疾病具有共同的危险因素和发病机制途径，但很少有研究探讨 HS 与呼吸疾病之间的关系。
这是一项横断面、病例对照、基于人群的研究，研究对象为 2002 年 1 月 1 日至 2012 年 12 月 31 日期间美国国家住院患者样本数据库。在住院期间使用 ICD-9-CM 代码识别 HS。多变量逻辑回归用于评估 HS 与呼吸诊断之间的调整后关联，并与匹配的对照组进行比较。
将 23767 例 HS 住院患者与 95068 例年龄和性别匹配的对照组进行比较。HS 患者患有哮喘的调整后优势比（OR）显著更高（OR：1.233；95%置信区间：[1.170-1.299]；P<0.001）、慢性气道阻塞（OR：1.532；95%置信区间：[1.419-1.651]；P<0.001）、结节病（OR：1.601；95%置信区间：[1.157-2.214]；P<0.001）和睡眠呼吸暂停（OR：1.274；95%置信区间：[1.182-1.374]；P<0.001）。
HS 与几种常见形式的呼吸疾病有关。了解这些关联可能有助于更好地识别 HS 患者的呼吸疾病。
