Hu Qianying, Chen Jianhua, Ma Jingjing, Li Yuting, Xu Yifeng, Yue Chaoyan, Cong Enzhao
Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 South Wanping Road, Shanghai, 200030, China.
School of Medicine, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.
Arch Womens Ment Health. 2024 Oct;27(5):837-844. doi: 10.1007/s00737-024-01466-w. Epub 2024 Apr 18.
Postpartum depression (PPD) brings adverse and serious consequences to both new parents and newborns. Neuroticism affects PPD, which remains controversial for confounding factors and reverse causality in cross-sectional research. Therefore, mendelian randomization (MR) study has been adopted to investigate their causal relationship.
This study utilized large-scale genome-wide association study genetic pooled data from three major databases: the United Kingdom Biobank, the European Bioinformatics Institute, and the FinnGen databases. The causal analysis methods used inverse variance weighting (IVW). The weighted median, MR-Egger method, MR-PRESSO test, and the leave-one-out sensitivity test have been used to examine the results' robustness, heterogeneity, and horizontal pleiotropy. The fixed effect model yielded the results of meta-analysis.
In the IVW model, a meta-analysis of the MR study showed that neuroticism increased the risk of PPD (OR, 1.17; 95% CI, 1.11-1.25, p < 0.01). Reverse analysis showed that PPD could not genetically predict neuroticism. There was no significant heterogeneity or horizontal pleiotropy bias in this result.
Our study suggests neuroticism is the risk factor for PPD from a gene perspective and PPD is not the risk factor for neuroticism. This finding may provide new insights into prevention and intervention strategies for PPD according to early detection of neuroticism.
产后抑郁症（PPD）会给初为人父母者和新生儿带来不良且严重的后果。神经质会影响产后抑郁症，在横断面研究中，由于混杂因素和反向因果关系，这一点仍存在争议。因此，采用了孟德尔随机化（MR）研究来探究它们之间的因果关系。
本研究利用了来自三个主要数据库的大规模全基因组关联研究遗传汇总数据：英国生物银行、欧洲生物信息学研究所和芬兰基因数据库。因果分析方法采用逆方差加权（IVW）。加权中位数、MR-Egger方法、MR-PRESSO检验和留一法敏感性检验已用于检验结果的稳健性、异质性和水平多效性。固定效应模型得出荟萃分析结果。
在IVW模型中，MR研究的荟萃分析表明，神经质增加了患PPD的风险（OR，1.17；95%CI，1.11 - 1.25，p < 0.01）。反向分析表明，PPD不能从基因上预测神经质。该结果不存在显著的异质性或水平多效性偏差。
我们的研究表明，从基因角度来看，神经质是PPD的危险因素，而PPD不是神经质的危险因素。这一发现可能为根据神经质的早期检测制定PPD的预防和干预策略提供新的见解。
