Center of Interventional Radiology and Vascular Surgery, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, Nanjing, Jiangsu, China.
Department of Oncology, Zhongda Hospital, Medical School, Southeast University, Nanjing, Jiangsu, China.
PLoS One. 2024 Apr 18;19(4):e0299949. doi: 10.1371/journal.pone.0299949. eCollection 2024.
Although there is evidence that ribonucleotide reductase subunit M2 (RRM2) is associated with numerous cancers, pan-cancer analysis has seldom been conducted. This study aimed to explore the potential carcinogenesis of RRM2 in pan-cancer using datasets from The Cancer Genome Atlas (TCGA).
Data from the UCSC Xena database were analyzed to investigate the differential expression of RRM2 across multiple cancer types. Clinical data such as age, race, sex, tumor stage, and status were acquired to analyze the influence of RRM2 on the clinical characteristics of the patients. The role of RRM2 in the onset and progression of multiple cancers has been examined in terms of genetic changes at the molecular level, including tumor mutational burden (TMB), microsatellite instability (MSI), biological pathway changes, and the immune microenvironment.
RRM2 was highly expressed in most cancers, and there was an obvious correlation between RRM2 expression and patient prognosis. RRM2 expression is associated with the infiltration of diverse immune and endothelial cells, immune checkpoints, tumor mutational burden (TMB), and microsatellite instability (MSI). Moreover, the cell cycle is involved in the functional mechanisms of RRM2.
Our pan-cancer study provides a comprehensive understanding of the carcinogenesis of RRM2 in various tumors.
尽管有证据表明核糖核苷酸还原酶亚单位 M2（RRM2）与许多癌症有关，但很少对泛癌进行分析。本研究旨在使用来自癌症基因组图谱（TCGA）的数据集探索 RRM2 在泛癌中的潜在致癌作用。
分析 UCSC Xena 数据库中的数据，以研究 RRM2 在多种癌症类型中的差异表达。获取年龄、种族、性别、肿瘤分期和状态等临床数据，以分析 RRM2 对患者临床特征的影响。从分子水平上的遗传变化，包括肿瘤突变负荷（TMB）、微卫星不稳定性（MSI）、生物途径变化和免疫微环境，研究 RRM2 在多种癌症发生和进展中的作用。
RRM2 在大多数癌症中高表达，并且 RRM2 表达与患者预后明显相关。RRM2 表达与多种免疫和内皮细胞浸润、免疫检查点、肿瘤突变负荷（TMB）和微卫星不稳定性（MSI）相关。此外，细胞周期涉及 RRM2 的功能机制。
我们的泛癌研究提供了对 RRM2 在各种肿瘤中致癌作用的全面理解。
