Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei 230032, Anhui Province, China; Key Laboratory of Population Health Across Life Cycle (AHMU), MOE, Hefei 230032, China; NHC Key Laboratory of study on abnormal gametes and reproductive tract, Hefei 230032, Anhui Province, China; Anhui Provincial Key Laboratory of Environment and Population Health Across the Life Course, Hefei 230032, Anhui Province, China.
Maternal and Child Health Care Center of Ma'anshan, No 24 Jiashan Road, Ma'anshan 243011, Anhui Province, China.
J Psychosom Res. 2024 Jun;181:111621. doi: 10.1016/j.jpsychores.2024.111621. Epub 2024 Feb 21.
The objective of this study was to investigate the associations between maternal exposure to anxiety during pregnancy and the susceptibility of offspring to eczema and allergic rhinitis and the possibility of sensitivity periods and cumulative effects.
The study's sample consisted of 3160 mother-child pairs from the Ma'anshan Birth Cohort Study. Maternal anxiety was repeatedly measured in the 1st, 2nd, and 3rd trimesters of pregnancy using the Chinese version of the Pregnancy-Related Anxiety Scale. Information regarding children's eczema and allergic rhinitis diagnoses was collected through parental reports at 12, 24, 36 and 48 months of age. Binary logistic regression models were used for statistical analysis and corrected for multiple comparisons using the false discovery rate (FDR) method.
Children whose mothers experienced anxiety throughout pregnancy had the highest odds of developing total eczema (aOR 1.45, 95% CI 1.02-2.07) and total allergic rhinitis (aOR 1.67, 95% CI 1.17-2.37) between the ages of 6 and 48 months. The higher the trajectory of the maternal anxiety scores throughout pregnancy, the higher the odds of total eczema (aOR 1.65, 95% CI 1.14-2.40) and allergic rhinitis (aOR 1.84, 95% CI 1.28-2.66) in their offspring. The association between maternal anxiety and children's eczema was mainly concentrated in the first 24 months, whereas the association with allergic rhinitis was mainly concentrated in the 36-48 months.
Maternal anxiety during any trimester of pregnancy, especially with a consistently high trajectory of anxiety scores, was associated with higher odds of children's eczema and allergic rhinitis.
本研究旨在探讨孕妇孕期焦虑暴露与子女易患湿疹和过敏性鼻炎的相关性，以及可能存在的敏感期和累积效应。
该研究的样本来自马鞍山出生队列研究中的 3160 对母婴。使用中文版妊娠相关焦虑量表在妊娠第 1、2 和 3 个 trimester 反复测量母亲的焦虑情况。通过父母在 12、24、36 和 48 个月时的报告，收集儿童湿疹和过敏性鼻炎诊断的信息。采用二元逻辑回归模型进行统计分析，并采用错误发现率（FDR）方法对多次比较进行校正。
孕期经历焦虑的母亲所生的孩子，在 6 至 48 个月时发生总湿疹（aOR 1.45，95%CI 1.02-2.07）和总过敏性鼻炎（aOR 1.67，95%CI 1.17-2.37）的可能性最高。孕期母亲焦虑评分轨迹越高，子女总湿疹（aOR 1.65，95%CI 1.14-2.40）和过敏性鼻炎（aOR 1.84，95%CI 1.28-2.66）的可能性越高。母亲焦虑与儿童湿疹的关联主要集中在前 24 个月，而与过敏性鼻炎的关联主要集中在 36-48 个月。
孕期任何 trimester 的焦虑，尤其是焦虑评分持续较高，与子女患湿疹和过敏性鼻炎的风险增加有关。
