Guangdong Provincial Key Laboratory of Environmental Pollution and Health, School of Environment, Jinan University, Guangzhou, 511436, China.
International Joint Research Center for Persistent Toxic Substances, Heilongjiang Institute of Labor Hygiene and Occupational Diseases, The Second Hospital of Heilongjiang Province, Harbin, 100028, China.
Environ Pollut. 2024 Jun 1;350:123995. doi: 10.1016/j.envpol.2024.123995. Epub 2024 Apr 16.
Per- and polyfluoroalkyl substances (PFASs) have potential carcinogenicity, immunotoxicity, and hepatotoxicity. Research has been conducted on PFAS exposure in people to discuss their potential health effects, excluding lung cancer. In this study, we recruited participants (n = 282) with lung cancer from Heilongjiang Province, northeast China. The PFAS concentrations were measured in their serum to fill the data gap of exposure, and relationships were explored in levels between PFASs and clinical indicators of tumor, immune and liver function. Ten PFASs were found in over 80 % of samples and their total concentrations were 5.27-152 ng/mL, with the highest level for perfluorooctanesulfonate (median: 12.4 ng/mL). Long-chain PFASs were the main congeners and their median concentration (20.5 ng/mL) was nearly three times to that of short-chain PFASs (7.61 ng/mL). Significantly higher concentrations of perfluorobutanoic acid, perfluorononanoic acid and perfluorohexanesulfonate were found in males than in females (p < 0.05). Serum levels of neuro-specific enolase were positively associated with perfluoropentanoic acid in all participants and were negatively associated with perfluorononanesulfonate in females (p < 0.05, multiple linear regression models). Exposure to PFAS mixture was significantly positively associated with the lymphocytic absolute value (difference: 0.224, 95% CI: 0.018, 0.470; p < 0.05, quantile g-computation models) and serum total bilirubin (difference: 2.177, 95% CI: 0.0335, 4.33; p < 0.05). Moreover, PFAS exposure can affect γ-glutamyl transpeptidase through several immune markers (p < 0.05, mediating test). Our results suggest that exposure to certain PFASs could interfere with clinical indicators in lung cancer patients. To our knowledge, this is the first study to detect serum PFAS occurrence and check their associations with clinical indicators in lung cancer patients.
全氟和多氟烷基物质 (PFAS) 具有潜在的致癌性、免疫毒性和肝毒性。已经对人体中 PFAS 暴露进行了研究，以讨论其潜在的健康影响，但不包括肺癌。在这项研究中，我们招募了来自中国东北黑龙江省的 282 名肺癌患者作为参与者。测量了他们血清中的 PFAS 浓度，以填补暴露数据的空白，并探讨了 PFAS 水平与肿瘤、免疫和肝功能临床指标之间的关系。在超过 80%的样本中发现了十种 PFAS，其总浓度为 5.27-152ng/mL，其中全氟辛烷磺酸的浓度最高（中位数：12.4ng/mL）。长链 PFAS 是主要的同系物，其浓度中位数（20.5ng/mL）几乎是短链 PFAS 的三倍（7.61ng/mL）。男性血清中全氟丁酸、全氟壬酸和全氟己烷磺酸的浓度明显高于女性（p<0.05）。在所有参与者中，神经特异性烯醇化酶的血清水平与全氟戊酸呈正相关，而在女性中与全氟壬烷磺酸盐呈负相关（p<0.05，多元线性回归模型）。PFAS 混合物的暴露与淋巴细胞绝对值呈显著正相关（差值：0.224，95%置信区间：0.018，0.470；p<0.05，分位数 g 计算模型）和血清总胆红素（差值：2.177，95%置信区间：0.0335，4.33；p<0.05）。此外，PFAS 暴露可以通过几种免疫标志物影响γ-谷氨酰转肽酶（p<0.05，中介测试）。我们的结果表明，接触某些 PFAS 可能会干扰肺癌患者的临床指标。据我们所知，这是首次检测肺癌患者血清 PFAS 发生情况并检查其与临床指标相关性的研究。
