近三倍体Ph阳性白血病

Near-triploid Ph-positive leukemia.

作者信息

Ohtaki K, Abe R, Tebbi C K, de los Santos R, Han T, Sandberg A A

出版信息

Cancer Genet Cytogenet. 1985 Oct;18(2):113-21. doi: 10.1016/0165-4608(85)90061-5.

Abstract

Tetraploid populations have been observed in various types of leukemia, but relatively few reports exist of triploid cell populations in acute or chronic leukemia. We report two cases of Ph-positive leukemia with a modal triploid cell population. Examination of peripheral blood from a 3-year-old boy with Ph-positive acute lymphoblastic leukemia (ALL) and a 68-year-old male with Ph-positive chronic myelocytic leukemia (CML) in blastic crisis revealed modal populations of 72 and 63 chromosomes, respectively. G-banding analysis of both cases revealed the following: karyotypic instability (no clonality), dominant trisomy, and the random association of the Ph chromosome with gains and losses of chromosomes involved in this translocation. The cytogenetic evidence obtained suggests that the triploid cell populations were not derived from a duplication of a hypodiploid cell population, but resulted from random loss of chromosomes from tetraploid cell populations derived from duplication of pseudodiploid cells.

摘要

在各类白血病中均观察到四倍体细胞群，但关于急性或慢性白血病中三倍体细胞群的报道相对较少。我们报告了两例具有三倍体细胞众数的Ph阳性白血病病例。对一名患有Ph阳性急性淋巴细胞白血病（ALL）的3岁男孩和一名处于急变期的Ph阳性慢性粒细胞白血病（CML）的68岁男性的外周血进行检查发现，其众数染色体数分别为72条和63条。对这两例病例的G显带分析显示如下情况：核型不稳定（无克隆性）、显性三体以及Ph染色体与该易位所涉及的染色体增减的随机关联。所获得的细胞遗传学证据表明，三倍体细胞群并非源自亚二倍体细胞群的复制，而是源自假二倍体细胞复制产生的四倍体细胞群中染色体的随机丢失。