Duplication of Ph and of 9q+ chromosomes during the blastic transformation of a CML case.
作者信息
Avanzi G C, Giovinazzo B, Saglio G, Guerrasio A, Rosso A, Bertini M, Resegotti L, Pegoraro L
机构信息
Istituto di Medicina Interna dell'Università di Torino, Italy.
出版信息
Cancer Genet Cytogenet. 1987 Nov;29(1):57-63. doi: 10.1016/0165-4608(87)90030-6.
PMID:3478129
Abstract
We describe the blastic transformation of a case of chronic myelocytic leukemia in which, among other abnormalities, one extra Philadelphia and one extra 9q+ were observed. Molecular studies and analysis of the clonal evolution of the karyotype led to the interpretation of such an unusual finding as the result of nondisjunction, rather than of a double t(9;22) translocation.
摘要
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