染色体与人类癌症和白血病的病因。第四十七部分。急性淋巴细胞白血病中的严重亚二倍体和染色体聚集
Chromosomes and causation of human cancer and leukemia. XLVII. severe hypodiploidy and chromosome conglomerations in ALL.
作者信息
Sandberg A A, Wake N, Kohno S
出版信息
Cancer Genet Cytogenet. 1982 Apr;5(4):293-307. doi: 10.1016/0165-4608(82)90095-4.
A case of acute lymphoblastic leukemia (ALL) of the L1 type with severe hypodiploidy in the marrow cells (modal chromosome number, 36) is described. In addition, most of the metaphases contained chromosome conglomerations which consisted of varying numbers of chromosomes and appeared similar to conglomerations previously observed by us in a case of chronic myelocytic leukemia (CML) in the blastic phase (BP), where some cells contained less than 20 chromosomes. The karyotype of the ALL cells of our case was similar to those of published near-haploid ALL cases, possibly indicative of a common pathway of cytogenetic evolution.
本文描述了一例L1型急性淋巴细胞白血病（ALL），其骨髓细胞严重亚二倍体（众数染色体数为36）。此外，大多数中期细胞含有染色体聚集体，这些聚集体由数量不等的染色体组成，看起来与我们之前在一例慢性粒细胞白血病（CML）急变期（BP）中观察到的聚集体相似，在该例中一些细胞所含染色体少于20条。我们病例中ALL细胞的核型与已发表的近单倍体ALL病例相似，这可能表明细胞遗传学进化存在共同途径。
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