Hagemeijer A, de Klein A, Gödde-Salz E, Turc-Carel C, Smit E M, van Agthoven A J, Grosveld G C
Cancer Genet Cytogenet. 1985 Oct;18(2):95-104. doi: 10.1016/0165-4608(85)90059-7.
In two patients with chronic myeloid leukemia (CML), the nature of the chromosomal rearrangement giving rise to "masked" Ph has been studied by in situ hybridization of human c-abl sequences. The c-abl probes hybridized to the 22q11 region of the "masked" Ph, demonstrating that translocation of sequences from 9q34 to the Ph did occur exactly as in standard Ph or in other types of variants previously studied. These results provide additional evidence for the occurrence of a constant molecular rearrangement in Ph-positive CML.
在两名慢性髓性白血病（CML）患者中，通过人c-abl序列的原位杂交研究了导致“隐匿”Ph染色体重排的性质。c-abl探针与“隐匿”Ph染色体的22q11区域杂交，表明从9q34到Ph染色体的序列易位确实如在标准Ph染色体或先前研究的其他类型变异体中一样发生。这些结果为Ph阳性CML中恒定分子重排的发生提供了额外证据。
