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J Exp Med. 1986 Nov 1;164(5):1389-96. doi: 10.1084/jem.164.5.1389.
2
Persistence of CML despite deletion of rearranged bcr/c-abl sequences.尽管重排的bcr/c-abl序列缺失，但慢性粒细胞白血病仍持续存在。
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Breakpoints on chromosomes 9 and 22 in Philadelphia chromosome-positive chronic myelogenous leukemia (CML). Amplification of rearranged c-abl oncogenes in CML blast crisis.费城染色体阳性慢性髓性白血病（CML）中9号和22号染色体的断点。CML急变期重排的c-abl癌基因的扩增。
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Acquired homozygosity of the rearranged bcr allele during the acute leukemic phase of a patient with Ph-negative chronic myeloid leukemia.Ph阴性慢性髓性白血病患者急性白血病阶段重排的bcr等位基因获得性纯合性。
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Chronic myelogenous leukemia: amplification of a rearranged c-abl oncogene in both chronic phase and blast crisis.慢性粒细胞白血病：在慢性期和急变期均存在重排的c-abl癌基因扩增。
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Unique fusion of bcr and c-abl genes in Philadelphia chromosome positive acute lymphoblastic leukemia.费城染色体阳性急性淋巴细胞白血病中bcr和c-abl基因的独特融合
Cell. 1987 Oct 9;51(1):33-40. doi: 10.1016/0092-8674(87)90007-9.

引用本文的文献

1
Philadelphia-positive chronic myelogenous leukemia with breakpoint 5' of the breakpoint cluster region but within the bcr gene.
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2
Bone marrow transplantation. Part I--Allogeneic.骨髓移植。第一部分——同种异体移植。
West J Med. 1989 Dec;151(6):638-43.
3
Philadelphia chromosome-positive chronic myelogenous leukemia with deleted fusion of BCR and ABL genes.伴有BCR和ABL基因缺失融合的费城染色体阳性慢性粒细胞白血病
Jpn J Cancer Res. 1990 Jan;81(1):35-42. doi: 10.1111/j.1349-7006.1990.tb02504.x.
4
T-cell immunity to the joining region of p210BCR-ABL protein.针对p210BCR-ABL蛋白连接区的T细胞免疫
Proc Natl Acad Sci U S A. 1992 Feb 15;89(4):1468-72. doi: 10.1073/pnas.89.4.1468.

本文引用的文献

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Evidence for a multistep pathogenesis of chronic myelogenous leukemia.慢性粒细胞白血病多步骤发病机制的证据。
Blood. 1981 Jul;58(1):158-63.
2
A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia.在慢性粒细胞白血病中，一种细胞癌基因易位至费城染色体。
Nature. 1982 Dec 23;300(5894):765-7. doi: 10.1038/300765a0.
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Late-appearing Philadelphia chromosome in two patients with chronic myelogenous leukemia.两名慢性粒细胞白血病患者中出现较晚的费城染色体。
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4
Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA.从小鼠骨髓瘤肿瘤总RNA中纯化小鼠免疫球蛋白重链信使RNA。
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5
Translocation of c-ab1 oncogene correlates with the presence of a Philadelphia chromosome in chronic myelocytic leukaemia.c - ab1癌基因的易位与慢性粒细胞白血病中费城染色体的存在相关。
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6
Is the chromosomal region 9q34 always involved in variants of the Ph1 translocation?染色体区域9q34是否总是参与费城染色体易位的变异？
Cancer Genet Cytogenet. 1984 Sep;13(1):1-16. doi: 10.1016/0165-4608(84)90083-9.
7
Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22.费城染色体断点聚集在22号染色体上一个有限的区域——bcr内。
Cell. 1984 Jan;36(1):93-9. doi: 10.1016/0092-8674(84)90077-1.
8
An 8-kilobase abl RNA transcript in chronic myelogenous leukemia.慢性粒细胞白血病中的一种8千碱基abl RNA转录本。
Proc Natl Acad Sci U S A. 1984 Sep;81(18):5648-52. doi: 10.1073/pnas.81.18.5648.
9
Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining.信件：通过喹吖因荧光和吉姆萨染色鉴定出慢性粒细胞白血病中一种新的一致染色体异常。
Nature. 1973 Jun 1;243(5405):290-3. doi: 10.1038/243290a0.
10
DNA content and DNA-based centromeric index of the 24 human chromosomes.24条人类染色体的DNA含量及基于DNA的着丝粒指数
Science. 1973 Mar 16;179(4078):1126-9. doi: 10.1126/science.179.4078.1126.

尽管在急变期重排的bcr/c-abl序列缺失，但慢性粒细胞白血病仍持续存在。

Persistence of chronic myelocytic leukemia despite deletion of rearranged bcr/c-abl sequences in blast crisis.

作者信息

Bartram C R, Janssen J W, Becher R, de Klein A, Grosveld G

出版信息

J Exp Med. 1986 Nov 1;164(5):1389-96. doi: 10.1084/jem.164.5.1389.

DOI:10.1084/jem.164.5.1389
PMID:3464689
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2188457/
Abstract

We report on a Ph+ chronic myelocytic leukemia (CML) case, cytogenetically characterized by the occurrence of a second Philadelphia (Ph) chromosome in lymphoid blast crisis of T cell lineage. In situ hybridization analyses showed a deletion of translocated c-abl sequences, present on the Ph during chronic state, from both Ph in acute state. Moreover, Southern blot analyses of blastic cells exhibited a rearrangement within bcr, but a deletion of 5' bcr sequences, and Northern blots failed to detect the hybrid 8.5 kb bcr/c-abl transcript usually observed in Ph+ CML.

摘要

我们报告了1例Ph+慢性粒细胞白血病（CML）病例，其细胞遗传学特征为在T细胞系淋巴母细胞危象中出现第二条费城（Ph）染色体。原位杂交分析显示，在慢性期存在于Ph染色体上的易位c-abl序列在急性期从两条Ph染色体上均缺失。此外，母细胞的Southern印迹分析显示bcr内发生重排，但5'bcr序列缺失，Northern印迹未能检测到Ph+CML中通常观察到的8.5kb bcr/c-abl杂交转录本。