尽管在急变期重排的bcr/c-abl序列缺失，但慢性粒细胞白血病仍持续存在。
Persistence of chronic myelocytic leukemia despite deletion of rearranged bcr/c-abl sequences in blast crisis.
作者信息
Bartram C R, Janssen J W, Becher R, de Klein A, Grosveld G
出版信息
J Exp Med. 1986 Nov 1;164(5):1389-96. doi: 10.1084/jem.164.5.1389.
Abstract
We report on a Ph+ chronic myelocytic leukemia (CML) case, cytogenetically characterized by the occurrence of a second Philadelphia (Ph) chromosome in lymphoid blast crisis of T cell lineage. In situ hybridization analyses showed a deletion of translocated c-abl sequences, present on the Ph during chronic state, from both Ph in acute state. Moreover, Southern blot analyses of blastic cells exhibited a rearrangement within bcr, but a deletion of 5' bcr sequences, and Northern blots failed to detect the hybrid 8.5 kb bcr/c-abl transcript usually observed in Ph+ CML.
摘要
我们报告了1例Ph+慢性粒细胞白血病（CML）病例，其细胞遗传学特征为在T细胞系淋巴母细胞危象中出现第二条费城（Ph）染色体。原位杂交分析显示，在慢性期存在于Ph染色体上的易位c-abl序列在急性期从两条Ph染色体上均缺失。此外，母细胞的Southern印迹分析显示bcr内发生重排，但5'bcr序列缺失，Northern印迹未能检测到Ph+CML中通常观察到的8.5kb bcr/c-abl杂交转录本。
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A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia.在慢性粒细胞白血病中，一种细胞癌基因易位至费城染色体。
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Translocation of c-ab1 oncogene correlates with the presence of a Philadelphia chromosome in chronic myelocytic leukaemia.c - ab1癌基因的易位与慢性粒细胞白血病中费城染色体的存在相关。
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