Center for AIE Research, Shenzhen Key Laboratory of Polymer Science and Technology, Guangdong Research Center for Interfacial Engineering of Functional Materials, College of Materials Science and Engineering, Shenzhen University, Shenzhen, 518060, China.
School of Science and Engineering, Shenzhen Institute of Aggregate Science and Technology, The Chinese University of Hong Kong, Shenzhen (CUHK-Shenzhen), Shenzhen, 2001 Longxiang Boulevard, Longgang District, Shenzhen City, Guangdong, 518172, China.
Angew Chem Int Ed Engl. 2024 Jun 21;63(26):e202401877. doi: 10.1002/anie.202401877. Epub 2024 May 21.
The second near-infrared (NIR-II, 1000-1700 nm) light-activated organic photothermal agent that synchronously enables satisfying NIR-II fluorescence imaging is highly warranted yet rather challenging on the basis of the overwhelming nonradiative decay. Herein, such an agent, namely TPABT-TD, was tactfully designed and constructed via employing benzo[c]thiophene moiety as bulky electron donor/π-bridge and tailoring the peripheral molecular rotors. Benefitting from its high electron donor-acceptor strength and finely modulated intramolecular motion, TPABT-TD simultaneously exhibits ultralong absorption in NIR-II region, intense fluorescence emission in the NIR-IIa (1300-1500 nm) region as nanoaggregates, and high photothermal conversion upon 1064 nm laser irradiation. Those intrinsic advantages endow TPABT-TD nanoparticles with prominent fluorescence/photoacoustic/photothermal trimodal imaging-guided NIR-II photothermal therapy against orthotopic 4T1 breast tumor with negligible adverse effect.
在此，通过采用苯并[c]噻吩作为大体积电子给体/π-桥，并对其外围的分子转子进行剪裁，我们巧妙地设计并构建了一种近红外二区（NIR-II，1000-1700nm）光激活有机光热剂 TPABT-TD。得益于其高电子给体-受体强度和精细调节的分子内运动，TPABT-TD 同时在 NIR-II 区具有超宽的吸收、作为纳米聚集体在 NIR-IIa（1300-1500nm）区具有强烈的荧光发射，并且在 1064nm 激光照射下具有高光热转换效率。这些内在优势使 TPABT-TD 纳米颗粒具有显著的荧光/光声/光热三模态成像引导的 NIR-II 光热治疗性能，可用于治疗原位 4T1 乳腺癌，且副作用可忽略不计。
