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增强单组分有机光治疗剂光动力和光热治疗性能策略的最新进展

Recent Advances in Strategies to Enhance Photodynamic and Photothermal Therapy Performance of Single-Component Organic Phototherapeutic Agents.

作者信息

Fang Laiping, Chen Zengzhen, Dai Jianan, Pan Yujin, Tu Yike, Meng Qi, Diao Yanzhao, Yang Shuaibo, Guo Wei, Li Liming, Liu Jinwu, Wen Hua, Hua Kelei, Hang Lifeng, Fang Jin, Meng Xianwei, Ma Ping'an, Jiang Guihua

机构信息

Guangdong Second Provincial General Hospital, School of Medicine, Jinan University, Xingangzhong Road 466, Guangzhou, 518037, P. R. China.

State Key Laboratory of Cryogenic Science and Technology, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Zhongguancun East Road 29, Beijing, 100190, P. R. China.

出版信息

Adv Sci (Weinh). 2025 Feb;12(7):e2409157. doi: 10.1002/advs.202409157. Epub 2025 Jan 10.

DOI:10.1002/advs.202409157
PMID:39792832
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11831458/
Abstract

Photodynamic therapy (PDT) and photothermal therapy (PTT) have emerged as promising treatment options, showcasing immense potential in addressing both oncologic and nononcologic diseases. Single-component organic phototherapeutic agents (SCOPAs) offer advantages compared to inorganic or multicomponent nanomedicine, including better biosafety, lower toxicity, simpler synthesis, and enhanced reproducibility. Nonetheless, how to further improve the therapeutic effectiveness of SCOPAs remains a challenging research area. This review delves deeply into strategies to improve the performance of PDT or PTT by optimizing the structural design of SCOPAs. These strategies encompass augmenting reactive oxygen species (ROS) generation, mitigating oxygen dependence, elevating light absorption capacity, broadening the absorption region, and enhancing the photothermal conversion efficiency (PCE). Additionally, this review also underscores the ideal strategies for developing SCOPAs with balanced PDT and PTT. Furthermore, the potential synergies are highlighted between PDT and PTT with other treatment modalities such as ferroptosis, gas therapy, chemotherapy, and immunotherapy. By providing a comprehensive analysis of these strategies, this review aspires to serve as a valuable resource for clinicians and researchers, facilitating the wider application and advancement of SCOPAs-mediated PDT and PTT.

摘要

光动力疗法（PDT）和光热疗法（PTT）已成为颇具前景的治疗选择，在治疗肿瘤和非肿瘤疾病方面展现出巨大潜力。与无机或多组分纳米药物相比，单组分有机光治疗剂（SCOPA）具有诸多优势，包括更好的生物安全性、更低的毒性、更简单的合成方法以及更高的可重复性。尽管如此，如何进一步提高SCOPA的治疗效果仍是一个具有挑战性的研究领域。本综述深入探讨了通过优化SCOPA的结构设计来提高PDT或PTT性能的策略。这些策略包括增加活性氧（ROS）的生成、减轻对氧气的依赖、提高光吸收能力、拓宽吸收区域以及提高光热转换效率（PCE）。此外，本综述还强调了开发具有平衡PDT和PTT的SCOPA的理想策略。此外，还突出了PDT和PTT与其他治疗方式（如铁死亡、气体疗法、化疗和免疫疗法）之间的潜在协同作用。通过对这些策略进行全面分析，本综述旨在为临床医生和研究人员提供有价值的参考资源，促进SCOPA介导的PDT和PTT的更广泛应用和发展。

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