Sordelli D O, Cerquetti M C, el-Tawil G, Ramwell P W, Hooke A M, Bellanti J A
Eur J Respir Dis. 1985 Aug;67(2):118-27.
In chronic P. aeruginosa infection, lung tissue damage is induced by either the microorganism or the inflammatory response. We investigated, in an animal model, whether a non-steroidal anti-inflammatory drug, ibuprofen, reduced lung inflammation produced by P. aeruginosa. Lung lavages, pulmonary clearance of P. aeruginosa and lung pathology were studied in CD-1 mice injected with sodium ibuprofenate. A single dose of the drug, injected immediately after 30 min exposure to the P. aeruginosa aerosol, decreased the recruitment of granulocytes into airways in a dose-dependent manner. Pretreatment with 2 doses of the drug 18 and 6 h before the P. aeruginosa challenge was even more effective. The kinetics of changes in prostaglandin E2, 6-keto-prostaglandin F1 alpha and thromboxane B2 concentrations in lung lavage fluids after P. aeruginosa aerosol were also modified by ibuprofen. Moreover, ibuprofen treatment did not impair lung clearance of the challenge microorganisms, and the animals had less inflammation of the lungs.
在慢性铜绿假单胞菌感染中，肺组织损伤是由微生物或炎症反应引起的。我们在动物模型中研究了一种非甾体抗炎药布洛芬是否能减轻铜绿假单胞菌引起的肺部炎症。对注射了布洛芬钠的CD-1小鼠进行了肺灌洗、铜绿假单胞菌的肺清除及肺病理学研究。在暴露于铜绿假单胞菌气雾剂30分钟后立即注射单剂量药物，以剂量依赖的方式减少了粒细胞向气道的募集。在铜绿假单胞菌攻击前18小时和6小时用两剂药物进行预处理效果更佳。布洛芬还改变了铜绿假单胞菌气雾剂后肺灌洗液中前列腺素E2、6-酮-前列腺素F1α和血栓素B2浓度的变化动力学。此外，布洛芬治疗并未损害对攻击微生物的肺清除能力，且动物的肺部炎症较轻。
