Blackwelder W C, Elston R C
Genet Epidemiol. 1985;2(1):85-97. doi: 10.1002/gepi.1370020109.
An analytical study is conducted of the properties of statistical tests to detect linkage between a disease locus and a very polymorphic marker locus when data on sib pairs are available. In most instances the most powerful test is the test based on the mean number of marker alleles shared identical by descent by the two members of a sib pair, and the most efficient sampling strategy is almost always to sample only pairs with both sibs affected. We show it is valid to use the information from all possible sib pairs as though they came from separate families when data on sibships of size three or larger are available, though more power may be obtained if different weights are given to the different sibship sizes.
当有同胞对的数据时，对用于检测疾病位点与高度多态性标记位点之间连锁的统计检验的性质进行了分析研究。在大多数情况下，最具效力的检验是基于同胞对的两个成员通过血缘共享的相同标记等位基因的平均数的检验，并且最有效的抽样策略几乎总是只对两个同胞都患病的对进行抽样。我们表明，当有大小为三或更大的同胞组的数据时，使用来自所有可能同胞对的信息就好像它们来自不同家庭一样是有效的，尽管如果对不同的同胞组大小赋予不同的权重，可能会获得更大的效力。
