Department of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, No. 389 Xincun Road, Shanghai, 200065, China.
Department of Oncology, Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University, Shanghai, China.
Respir Res. 2024 Apr 18;25(1):169. doi: 10.1186/s12931-024-02783-5.
To explore the efficacy of deep diaphragmatic breathing training (DEP) in patients with gastroesophageal reflux-induced chronic cough (GERC).
A randomized controlled study was conducted involving 60 GERC patients who were divided into the intervention group and the control group (each with 30 patients). Both groups received routine medication treatment for GERC, while the intervention group received DEP training additionally. Both groups were evaluated by cough symptom scores, Hull airway reflux questionnaire (HARQ), gastroesophageal reflux diagnostic questionnaire (GerdQ), generalized anxiety disorder scale-7 (GAD-7), patient health questionnaire-9 (PHQ-9), Pittsburgh sleep quality index (PSQI), the Leicester cough questionnaire (LCQ), as well as capsaicin cough sensitivity testing, B-ultrasound and surface electromyography (sEMG) of the diaphragmatic muscles before and after treatment. The cough resolution rate and changes of the above indictors was compared between the two groups after eight weeks of treatment.
After eight weeks of treatment, cough symptoms improved in both groups, but the cough resolution rate in the intervention group of 94% was significantly higher than that in the control group of 77% (χ = 6.402, P = 0.041). The intervention group showed significant improvements to the control group in GerdQ (6.13(0.35) VS 6.57(0.77)), GAD-7 (0(0;1) VS 1(0;3)), PSQI (2(1;3) VS 4(3;6)), LCQ (17.19(1.56) VS 15.88(1.92)) and PHQ-9 (0(0;0) VS 0(0;3)) after treatment. Compared to control group, sEMG activity of the diaphragmatic muscle was significantly increased in the intervention group after treatment, measured during DEP (79.00(2.49) VS 74.65 (1.93)) and quiet breathing (72.73 (1.96) VS 67.15 (2.48)).
DEP training can improve cough symptoms as an adjunctive treatment in GERC patients.
The protocol was registered in February 2, 2022 via the Chinese Clinical Trials Register ( http://www.chictr.org.cn/ ) [ChiCTR2200056246].
探讨深度膈肌呼吸训练（DEP）对胃食管反流引起的慢性咳嗽（GERC）患者的疗效。
采用随机对照研究，纳入 60 例 GERC 患者，分为干预组和对照组（每组 30 例）。两组均给予 GERD 常规药物治疗，干预组在此基础上给予 DEP 训练。两组均在治疗前及治疗 8 周后进行咳嗽症状评分、赫尔空气反流问卷（HARQ）、胃食管反流病诊断问卷（GerdQ）、广泛性焦虑障碍量表-7（GAD-7）、患者健康问卷-9（PHQ-9）、匹兹堡睡眠质量指数（PSQI）、莱斯特咳嗽问卷（LCQ）、辣椒素咳嗽敏感性检测、B 超及膈肌表面肌电图（sEMG）检查，比较两组治疗 8 周后的咳嗽缓解率及上述指标的变化。
治疗 8 周后，两组咳嗽症状均有改善，但干预组的咳嗽缓解率为 94%，明显高于对照组的 77%（χ = 6.402，P = 0.041）。干预组在 GerdQ（6.13（0.35）比 6.57（0.77））、GAD-7（0（0；1）比 1（0；3））、PSQI（2（1；3）比 4（3；6））、LCQ（17.19（1.56）比 15.88（1.92））和 PHQ-9（0（0；0）比 0（0；3））方面的改善均明显优于对照组。与对照组相比，干预组在 DEP 期间（79.00（2.49）比 74.65（1.93））和安静呼吸时（72.73（1.96）比 67.15（2.48））膈肌肌肉的 sEMG 活动明显增加。
DEP 训练可作为 GERD 患者的辅助治疗方法，改善咳嗽症状。
该方案于 2022 年 2 月 2 日通过中国临床试验注册中心（http://www.chictr.org.cn/）进行注册[ChiCTR2200056246]。
