Meng Sicen, Lu Wubing, Li Zhi, Zhou Yinxin, Shi Shanjun, Zhao Hui, Li Mingcai, Li Yan
School of Public Health, Health Science Center, Ningbo University, Ningbo, China.
School of Basic Medical Sciences and Zhejiang Key Laboratory of Pathophysiology, Health Science Center, Ningbo University, Ningbo, China.
Immunol Invest. 2024 Jul;53(5):788-799. doi: 10.1080/08820139.2024.2341233. Epub 2024 Apr 18.
Gout is a chronic inflammatory diseases caused by monosodium urate crystal deposition. However, the role of interleukin (IL)-36 in gout has not dbeen elucidated.
We enrolled 75 subjects, including 20 healthy controls (HC), 30 patients with acute gout attack and 25 patients in remission. Baseline data were obtained through clinical interrogation and laboratory data were obtained through tests of blood samples. Serum levels of IL-36α were detected using enzyme-linked immunosorbent assay. Spearman correlation analysis was used to investigate the correlation of IL-36α with other parameters. The diagnostic value of IL-36α was demonstrated using a receiver operating characteristic curve.
The serum IL-36α level of gout patients in acute attack and remission stage was significantly higher than that of HC. Serum IL-36α was positively correlated with alanine transaminase (ALT) and aspartate transaminase (AST). Serum amyloid A (SAA) levels positively correlated with C-reactive protein levels and erythrocyte sedimentation rates. Glutamyl transpeptidase levels positively correlated with AST and ALT levels.
In conclusion, serum IL-36α levels were elevated in patients with gout and correlated with the clinical markers of inflammation. Our findings suggest that IL-36α may be a novel inflammatory indicator for gout.
痛风是一种由尿酸单钠晶体沉积引起的慢性炎症性疾病。然而，白细胞介素（IL）-36在痛风中的作用尚未阐明。
我们纳入了75名受试者，包括20名健康对照者（HC）、30名急性痛风发作患者和25名缓解期患者。通过临床问诊获取基线数据，通过血液样本检测获取实验室数据。采用酶联免疫吸附测定法检测血清IL-36α水平。采用Spearman相关性分析研究IL-36α与其他参数的相关性。使用受试者工作特征曲线来证明IL-36α的诊断价值。
急性发作期和缓解期痛风患者的血清IL-36α水平显著高于健康对照者。血清IL-36α与丙氨酸转氨酶（ALT）和天冬氨酸转氨酶（AST）呈正相关。血清淀粉样蛋白A（SAA）水平与C反应蛋白水平和红细胞沉降率呈正相关。谷氨酰转肽酶水平与AST和ALT水平呈正相关。
总之，痛风患者血清IL-36α水平升高，且与炎症临床指标相关。我们的研究结果表明，IL-36α可能是痛风的一种新型炎症指标。
