Zhejiang Key Laboratory of Pathophysiology, Health Science Center, Ningbo University, Ningbo 315211, China.
Zhejiang Key Laboratory of Pathophysiology, Health Science Center, Ningbo University, Ningbo 315211, China; Department of Clinical Laboratory, Ningbo No. 6 Hospital Affiliated to Ningbo University, Ningbo 315040, China.
Int Immunopharmacol. 2023 Sep;122:110621. doi: 10.1016/j.intimp.2023.110621. Epub 2023 Jul 10.
Gout is a common metabolic rheumatic disease, and there have been no reports on the serum levels of interleukin (IL)-41 in gout patients. The purpose of this study was to therefore determine the expression of IL-41 in the serum of gout patients.
Eighty-one participants were enrolled in this study, including 34 patients with acute gout, 27 gout patients in remission, and 20 healthy controls (HCs). Baseline data were obtained through interviews and laboratory parameters were acquired via blood sample testing. We measured serum IL-41 concentrations with an enzyme-linked immunosorbent assay, and executed Spearman's correlation analysis to investigate the correlation between IL-41 and other parameters, and the diagnostic value for IL-41 was demonstrated using a receiver operating characteristic curve. Multivariate analysis was conducted by adopting logistic regression.
Serum IL-41 concentrations in acute-gout patients were higher than those in HCs and there was no significant difference in serum IL-41 levels between remission gout patients and HCs. In addition, IL-41 was positively correlated with white blood cell count, erythrocyte sedimentation rate, and C-reactive protein and serum amyloid A concentrations, while it was negatively correlated with triglyceride levels. IL-41 showed good diagnostic value for gout, and the combination of IL-41 and uric acid produced a superior diagnostic value. We also noted that IL-41 was an independent risk factor for acute gout.
This study revealed that serum IL-41 was elevated in patients with acute gout, and suggests that IL-41 may constitute a novel diagnostic marker for acute gout.
痛风是一种常见的代谢性风湿病，目前尚无关于痛风患者白细胞介素（IL）-41 血清水平的报道。本研究旨在测定痛风患者血清中 IL-41 的表达。
本研究纳入了 81 名参与者，包括 34 名急性痛风患者、27 名缓解期痛风患者和 20 名健康对照者（HCs）。通过访谈获得基线数据，并通过血液样本检测获得实验室参数。我们采用酶联免疫吸附试验测定血清 IL-41 浓度，通过 Spearman 相关分析探讨 IL-41 与其他参数的相关性，并通过受试者工作特征曲线评估 IL-41 的诊断价值。采用 logistic 回归进行多变量分析。
急性痛风患者的血清 IL-41 浓度高于 HCs，缓解期痛风患者的血清 IL-41 水平与 HCs 无显著差异。此外，IL-41 与白细胞计数、红细胞沉降率和 C 反应蛋白以及血清淀粉样蛋白 A 浓度呈正相关，与甘油三酯水平呈负相关。IL-41 对痛风具有良好的诊断价值，且 IL-41 与尿酸联合应用具有更好的诊断价值。我们还发现，IL-41 是急性痛风的独立危险因素。
本研究表明，急性痛风患者的血清 IL-41 水平升高，提示 IL-41 可能成为急性痛风的一种新的诊断标志物。
