Zhang Li, You Hai-Zhang, Wang Guo-Hui, Xu Wei, Li Jian-Shan, Zhao Qing-Liang, Du Shu
Department of Hospital-Acquired Infection Control, Lixiang Eye Hospital of Soochow University, Suzhou 215021, Jiangsu Province, China.
Department of Administrative Office, Lixiang Eye Hospital of Soochow University, Suzhou 215021, Jiangsu Province, China.
Int J Ophthalmol. 2024 Apr 18;17(4):700-706. doi: 10.18240/ijo.2024.04.14. eCollection 2024.
To investigate the types of bacteria in patients with eye infections in Suzhou and their drug resistance to commonly used antibacterial drugs.
The clinical data of 155 patients were retrospectively collected in this study, and the pathogenic bacteria species and drug resistance of each pathogenic bacteria were analyzed.
Among the 155 patients (age from 12 to 87 years old, with an average age of 57, 99 males and 56 females) with eye infections (160 eyes: 74 in the left eye, 76 in the right eye and 5 in both eyes, all of which were exogenous), 71 (45.81%) strains were gram-positive bacteria, 23 (14.84%) strains were gram-negative bacteria and 61 (39.35%) strains were fungi. Gram-positive bacteria were highly resistant to penicillin and erythromycin (78.87% and 46.48% respectively), but least resistant to vancomycin at 0. Gram-negative bacteria were highly resistant to cefoxitin and compound sulfamethoxazole (100% and 95.65% respectively), but least resistant to meropenem at 0. Comparison of the resistance of gram-positive and gram-negative bacteria to some drugs revealed statistically significant differences (<0.05) in the resistance of both to cefoxitin, cotrimoxazole, levofloxacin, cefuroxime, ceftriaxone and ceftazidime, and both had higher rates of resistance to gram-negative bacteria than to gram-positive bacteria. The distribution of bacterial infection strains showed that was the most common strain in the conjunctiva, cornea, aqueous humor or vitreous body and other eye parts. Besides, and were also among the most common strains of conjunctival and corneal infections.
Gram-positive bacteria are the dominant bacteria in eye infections, followed by gram-negative bacteria and fungi. Considering the resistance of gram-negative bacteria to multiple drugs, monitoring of bacteria should be strengthened in eye bacterial infections for effective prevention and control to reduce complications caused by eye infections.
调查苏州地区眼部感染患者的细菌种类及其对常用抗菌药物的耐药性。
本研究回顾性收集了155例患者的临床资料，分析了病原菌种类及各病原菌的耐药情况。
155例眼部感染患者（年龄12至87岁，平均年龄57岁，男性99例，女性56例）共160只眼（左眼74只，右眼76只，双眼5只，均为外源性感染），其中革兰阳性菌71株（45.81%），革兰阴性菌23株（14.84%），真菌61株（39.35%）。革兰阳性菌对青霉素和红霉素耐药率较高（分别为78.87%和46.48%），对万古霉素耐药率最低为0。革兰阴性菌对头孢西丁和复方磺胺甲恶唑耐药率较高（分别为100%和95.65%），对美罗培南耐药率最低为0。革兰阳性菌和革兰阴性菌对部分药物的耐药性比较显示，两者对头孢西丁、复方新诺明、左氧氟沙星、头孢呋辛、头孢曲松和头孢他啶的耐药性存在统计学差异（<0.05），且革兰阴性菌的耐药率均高于革兰阳性菌。细菌感染菌株分布显示，[此处原文缺失具体菌株名称]是结膜、角膜、房水或玻璃体等眼部各部位最常见的菌株。此外，[此处原文缺失具体菌株名称]也是结膜和角膜感染最常见的菌株之一。
革兰阳性菌是眼部感染的主要细菌，其次是革兰阴性菌和真菌。鉴于革兰阴性菌对多种药物耐药，眼部细菌感染应加强细菌监测，以有效防控，减少眼部感染引起的并发症。
