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宿主-病原体相互作用:角膜和眼后节内的两个故事

The Host-Pathogen Interplay: A Tale of Two Stories within the Cornea and Posterior Segment.

作者信息

Dempsey Michael P, Conrady Christopher D

机构信息

Department of Ophthalmology and Visual Sciences, Truhlsen Eye Center, University of Nebraska Medical Center, Omaha, NE 68105, USA.

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, USA.

出版信息

Microorganisms. 2023 Aug 12;11(8):2074. doi: 10.3390/microorganisms11082074.

DOI:10.3390/microorganisms11082074
PMID:37630634
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10460047/
Abstract

Ocular infectious diseases are an important cause of potentially preventable vision loss and blindness. In the following manuscript, we will review ocular immunology and the pathogenesis of herpesviruses and Pseudomonas aeruginosa infections of the cornea and posterior segment. We will highlight areas of future research and what is currently known to promote bench-to-bedside discoveries to improve clinical outcomes of these debilitating ocular diseases.

摘要

眼部感染性疾病是导致潜在可预防的视力丧失和失明的重要原因。在以下手稿中,我们将回顾眼部免疫学以及角膜和眼后段疱疹病毒和铜绿假单胞菌感染的发病机制。我们将重点介绍未来研究的领域以及目前已知的促进从实验室到临床转化的发现,以改善这些使人衰弱的眼部疾病的临床结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d35/10460047/c94e56c97e07/microorganisms-11-02074-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d35/10460047/354e647e8e21/microorganisms-11-02074-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d35/10460047/c94e56c97e07/microorganisms-11-02074-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d35/10460047/354e647e8e21/microorganisms-11-02074-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d35/10460047/c94e56c97e07/microorganisms-11-02074-g002.jpg

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Ophthalmology. 2023 Aug;130(8):863-871. doi: 10.1016/j.ophtha.2023.03.012. Epub 2023 Mar 22.
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The Role of C-X-C Chemokines in Staphylococcus aureus Endophthalmitis.C-X-C 趋化因子在金黄色葡萄球菌眼内炎中的作用。
Invest Ophthalmol Vis Sci. 2023 Mar 1;64(3):10. doi: 10.1167/iovs.64.3.10.
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Ocular immune privilege and retinal pigment epithelial cells.眼部免疫赦免与视网膜色素上皮细胞。
J Leukoc Biol. 2023 Mar 1;113(3):288-304. doi: 10.1093/jleuko/qiac016.
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J Neuroinflammation. 2023 Feb 4;20(1):25. doi: 10.1186/s12974-023-02712-1.
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