Ellis G L, Connole P W
J Am Dent Assoc. 1985 Oct;111(4):630-2. doi: 10.14219/jada.archive.1985.0166.
Paget's disease of the jaw has the following characteristics: slow progression of jaw enlargement; bilateral jaw involvement; often polyostotic, but not generalized skeletal disease; diffuse, irregular radiopaque areas of the jaw; elevated serum alkaline phosphatase level; and a biopsy specimen showing thick, irregular bone trabeculae with a mosaic pattern of reversal lines and numerous osteoblasts and osteoclasts in a fibrovascular stroma. Management of a patient with Paget's disease of bone usually is carried out by treating the symptoms of the disease as they arise. Bone can be removed for esthetic reasons when needed.
颌骨增大进展缓慢；双侧颌骨受累；常为多骨病变，但无全身性骨骼疾病；颌骨出现弥漫性、不规则的不透光区；血清碱性磷酸酶水平升高；活检标本显示骨小梁粗大、不规则，有反转线的镶嵌图案，在纤维血管间质中有大量成骨细胞和破骨细胞。骨佩吉特病患者的治疗通常是在出现疾病症状时对其进行对症治疗。必要时可出于美观原因切除骨骼。
